Florida State Road 405

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State Road 405 is a street making a sweeping arc in Titusville, Florida and providing a major access route for the Kennedy Space Center on nearby Merritt Island. It is locally known as South Street, Columbia Boulevard, and the NASA Causeway, South of Cheney Highway (SR 50), SR 405 is signed east-west; north of SR 50, SR 405 is signed north-south (it actually parallels Interstate 95 (SR 9) for 2.2 miles - from Cheney Highway to Constance Street - before veering off the northeast to become the residential South Street).

The northern terminus of SR 405 is an intersection with North Washington Avenue (US 1-SR 5) in downtown Titusville; the eastern terminus is at the Space Center entrance. In addition, SR 405 passes by Vectorspace Research Park (home of Astronaut Hall of Fame and U.S. Space Camp), Space Coast Regional Airport (formerly Ti-Co (Titusville-Cocoa) Airport) and Enchanted Forest Park.