FLOT1

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Flotillin 1
Identifiers
Symbol(s) FLOT1;
External IDs OMIM: 606998 MGI: 1100500 HomoloGene: 31337
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10211 14251
Ensembl ENSG00000137312 ENSMUSG00000059714
Uniprot O75955 Q3TJS0
Refseq NM_005803 (mRNA)
NP_005794 (protein)		 NM_008027 (mRNA)
NP_032053 (protein)
Location Chr 6: 30.8 - 30.82 Mb Chr 17: 35.43 - 35.44 Mb
Pubmed search [1] [2]

Flotillin 1, also known as FLOT1, is a human gene.[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: FLOT1 flotillin 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Bickel PE, Scherer PE, Schnitzer JE, et al. (1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins.". J. Biol. Chem. 272 (21): 13793–802. PMID 9153235. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.". J. Biol. Chem. 274 (18): 12702–9. PMID 10212252. 
  • Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.". J. Cell. Biochem. 75 (1): 147–59. PMID 10462713. 
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946. 
  • Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport.". Nature 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.". Blood 97 (4): 1141–3. PMID 11159550. 
  • Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.". Int. J. Biochem. Cell Biol. 33 (1): 53–64. PMID 11167132. 
  • Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMID 11481476. 
  • Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.". Mol. Biol. Cell 12 (10): 3031–45. PMID 11598189. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. PMID 14708344. 
  • Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein.". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID 15120622. 
  • Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. 
  • Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.". Mol. Biol. Cell 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMID 15469992. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.". Neurotoxicity research 6 (4): 245–57. PMID 15545008. 
  • Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. 
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