FLNA

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Filamin A, alpha (actin binding protein 280)
PDB rendering based on 2aav.
Available structures: 2aav, 2bp3, 2brq
Identifiers
Symbol(s)	FLNA; ABP-280; ABPX; DKFZp434P031; FLN; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; filamin A
External IDs	OMIM: 300017 HomoloGene: 1119
Gene ontology Molecular Function: • actin binding • signal transducer activity • transcription factor binding • actin filament binding Cellular Component: • nucleus • cytoplasm • actin cytoskeleton Biological Process: • cell motility • cell surface receptor linked signal transduction • nervous system development • actin cytoskeleton organization and biogenesis • positive regulation of transcription factor import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of transcription factor activity
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2316	n/a
Ensembl	ENSG00000196924	n/a
Uniprot	P21333	n/a
Refseq	NM_001456 (mRNA) NP_001447 (protein)	n/a (mRNA) n/a (protein)
Location	Chr X: 153.23 - 153.26 Mb	n/a
Pubmed search	[1]	n/a

Filamin A, alpha (actin binding protein 280), also known as FLNA, is a human gene.

Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.[supplied by OMIM]^[1]

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