FLI1

From Wikipedia, the free encyclopedia


Friend leukemia virus integration 1
PDB rendering based on 1fli.
Available structures: 1fli, 1x66
Identifiers
Symbol(s) FLI1; EWSR2; SIC-1
External IDs OMIM: 193067 MGI: 95554 HomoloGene: 55624
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2313 14247
Ensembl ENSG00000151702 ENSMUSG00000016087
Uniprot Q01543 Q544B3
Refseq NM_002017 (mRNA)
NP_002008 (protein)		 NM_008026 (mRNA)
NP_032052 (protein)
Location Chr 11: 128.07 - 128.19 Mb Chr 9: 32.17 - 32.23 Mb
Pubmed search [1] [2]

Friend leukemia virus integration 1, also known as FLI1, is a human gene.


[edit] Further reading

  • Ban J, Siligan C, Kreppel M, et al. (2007). "EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage.". Adv. Exp. Med. Biol. 587: 41–52. PMID 17163154. 
  • Prasad DD, Rao VN, Reddy ES (1992). "Structure and expression of human Fli-1 gene.". Cancer Res. 52 (20): 5833–7. PMID 1394211. 
  • Watson DK, Smyth FE, Thompson DM, et al. (1992). "The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors.". Cell Growth Differ. 3 (10): 705–13. PMID 1445800. 
  • Delattre O, Zucman J, Plougastel B, et al. (1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.". Nature 359 (6391): 162–5. doi:10.1038/359162a0. PMID 1522903. 
  • Baud V, Lipinski M, Rassart E, et al. (1992). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24.". Genomics 11 (1): 223–4. PMID 1765382. 
  • Bergeron D, Poliquin L, Kozak CA, Rassart E (1991). "Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas.". J. Virol. 65 (1): 7–15. PMID 1845910. 
  • Bhagirath T, Abe S, Nojima T, Yoshida MC (1995). "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma.". Genes Chromosomes Cancer 13 (2): 126–32. PMID 7542907. 
  • Liang H, Mao X, Olejniczak ET, et al. (1995). "Solution structure of the ets domain of Fli-1 when bound to DNA.". Nat. Struct. Biol. 1 (12): 871–5. PMID 7773776. 
  • May WA, Lessnick SL, Braun BS, et al. (1994). "The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.". Mol. Cell. Biol. 13 (12): 7393–8. PMID 8246959. 
  • Hromas R, May W, Denny C, et al. (1993). "Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neuroepithelioma.". Biochim. Biophys. Acta 1172 (1-2): 155–8. PMID 8439553. 
  • Magnaghi-Jaulin L, Masutani H, Robin P, et al. (1996). "SRE elements are binding sites for the fusion protein EWS-FLI-1.". Nucleic Acids Res. 24 (6): 1052–8. PMID 8604338. 
  • Barbeau B, Bergeron D, Beaulieu M, et al. (1996). "Characterization of the human and mouse Fli-1 promoter regions.". Biochim. Biophys. Acta 1307 (2): 220–32. PMID 8679708. 
  • Watson DK, Robinson L, Hodge DR, et al. (1997). "FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements.". Oncogene 14 (2): 213–21. doi:10.1038/sj.onc.1200839. PMID 9010223. 
  • Kwiatkowski BA, Bastian LS, Bauer TR, et al. (1998). "The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity.". J. Biol. Chem. 273 (28): 17525–30. PMID 9651344. 
  • Carrère S, Verger A, Flourens A, et al. (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.". Oncogene 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824. 
  • Zucman-Rossi J, Legoix P, Victor JM, et al. (1998). "Chromosome translocation based on illegitimate recombination in human tumors.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11786–91. PMID 9751743. 
  • Dalgleish P, Sharrocks AD (2000). "The mechanism of complex formation between Fli-1 and SRF transcription factors.". Nucleic Acids Res. 28 (2): 560–9. PMID 10606656. 
  • Knoop LL, Baker SJ (2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation.". J. Biol. Chem. 275 (32): 24865–71. doi:10.1074/jbc.M001661200. PMID 10827180. 
  • Spyropoulos DD, Pharr PN, Lavenburg KR, et al. (2000). "Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor.". Mol. Cell. Biol. 20 (15): 5643–52. PMID 10891501. 
  • Mastrangelo T, Modena P, Tornielli S, et al. (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor.". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD