Flat-field correction
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The goal of flat-field correction (or "flat-fielding") is to remove artifacts from 2-D images that are caused by variations in the pixel-to-pixel sensitivity of the detector and/or by distortions in the optical path. It is a standard calibration procedure in everything from pocket digital cameras to giant telescopes.
Flat fielding refers to the process of compensating for different gains and dark currents in a detector. Once a detector has been appropriately flat-fielded, a uniform signal will create a uniform output (hence flat-field). This then means any further signal is due from the phenomenon being detected and not a systematic error.
A flat-field consists of two numbers for each pixel, the pixel's gain and its dark current (or dark-frame). The pixel's gain is how the amount of signal given by the detector varies as a function of the amount of light (or equivalent). The gain is almost always a linear variable, as such the gain is given simply as the ratio of the input and output signals. The dark-current is the amount of signal given out by the detector when there is no incident light (hence dark frame). In many detectors this can also be a function of time, for example in astronomical telescopes it is common to take a dark-frame of the same time as the planned light exposure. The gain and dark-frame for optical systems can also be established by using a series of neutral density filters to give input/output signal information and applying a least squares fit to obtain the values for the dark current and gain.