FKBP10

From Wikipedia, the free encyclopedia

FK506 binding protein 10, 65 kDa

Identifiers

FKBP10; FKBP65; FLJ22041; hFKBP65

External IDs

OMIM: 607063 MGI: 104769 HomoloGene: 7718

Gene ontology
Molecular Function:	• peptidyl-prolyl cis-trans isomerase activity • calcium ion binding • protein binding • isomerase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• protein folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021939 (mRNA)
NP_068758 (protein)

NM_010221 (mRNA)
NP_034351 (protein)

Location

Chr 17: 37.22 - 37.23 Mb

Chr 11: 100.23 - 100.24 Mb

Pubmed search

[1]

[2]

FK506 binding protein 10, 65 kDa, also known as FKBP10, is a human gene.^[1]

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: FKBP10 FK506 binding protein 10, 65 kDa.

[edit] Further reading

Patterson CE, Schaub T, Coleman EJ, Davis EC (2001). "Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein.". Mol. Biol. Cell 11 (11): 3925–35. PMID 11071917.
Patterson CE, Gao J, Rooney AP, Davis EC (2002). "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family.". Genomics 79 (6): 881–9. doi:10.1006/geno.2002.6777. PMID 12036304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Won J, Kim M, Yi YW, et al. (2005). "A magnetic nanoprobe technology for detecting molecular interactions in live cells.". Science 309 (5731): 121–5. doi:10.1126/science.1112869. PMID 15994554.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.