FitzHugh–Nagumo model

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The FitzHugh-Nagumo model (named after Richard FitzHugh, 1922–2007) describes a prototype of an excitable system, i.e., a neuron.

If the external stimulus Iext exceeds a certain threshold value, the system will exhibit a characteristic excursion in phase space, before the variables v and w relax back to their rest values.

This behaviour is typical for spike generations (=short elevation of membrane voltage v) in a neuron after stimulation by an external input current.

The equations for this dynamical system read

\dot{v}=v-v^3 - w + I_{\rm ext}
\tau \dot{w} = v-a-b w.

The dynamics of this system can be nicely described by zapping between the left and right branch of the cubic nullcline.

The FitzHugh-Nagumo model is a simplified version of the Hodgkin-Huxley model which models in a detailed manner activation and deactivation dynamics of a spiking neuron. In the original papers of FitzHugh this model was called Bonhoeffer-van der Pol oscillator, since it contains the van der Pol oscillator as a special case for a = b = 0.

[edit] See also

[edit] References

  • FitzHugh R. (1955) Mathematical models of threshold phenomena in the nerve membrane. Bull. Math. Biophysics, 17:257--278
  • FitzHugh R. (1961) Impulses and physiological states in theoretical models of nerve membrane. Biophysical J. 1:445-466
  • FitzHugh R. (1969) Mathematical models of excitation and propagation in nerve. Chapter 1 (pp. 1-85 in H.P. Schwan, ed. Biological Engineering, McGraw-Hill Book Co., N.Y.)
  • Nagumo J., Arimoto S., and Yoshizawa S. (1962) An active pulse transmission line simulating nerve axon. Proc IRE. 50:2061–2070.

[edit] External links

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