FIS1

From Wikipedia, the free encyclopedia


Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
PDB rendering based on 1iyg.
Available structures: 1iyg, 1nzn, 1pc2
Identifiers
Symbol(s) FIS1; CGI-135; TTC11
External IDs OMIM: 609003 MGI: 1913687 HomoloGene: 41099
Orthologs
Human Mouse
Entrez 51024 66437
Ensembl n/a ENSMUSG00000019054
Uniprot n/a Q9CQ92
Refseq NM_016068 (mRNA)
NP_057152 (protein)		 NM_025562 (mRNA)
NP_079838 (protein)
Location n/a Chr 5: 137.25 - 137.25 Mb
Pubmed search [1] [2]

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae), also known as FIS1, is a human gene.[1]

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae).

[edit] Further reading

  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • James DI, Parone PA, Mattenberger Y, Martinou JC (2003). "hFis1, a novel component of the mammalian mitochondrial fission machinery.". J. Biol. Chem. 278 (38): 36373-9. doi:10.1074/jbc.M303758200. PMID 12783892. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948. 
  • Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003). "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.". Mol. Cell. Biol. 23 (15): 5409-20. PMID 12861026. 
  • Kikuchi M, Hatano N, Yokota S, et al. (2004). "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.". J. Biol. Chem. 279 (1): 421-8. doi:10.1074/jbc.M305623200. PMID 14561759. 
  • Suzuki M, Jeong SY, Karbowski M, et al. (2003). "The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.". J. Mol. Biol. 334 (3): 445-58. PMID 14623186. 
  • Dohm JA, Lee SJ, Hardwick JM, et al. (2004). "Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold.". Proteins 54 (1): 153-6. doi:10.1002/prot.10524. PMID 14705031. 
  • Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (2004). "Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology.". J. Cell. Sci. 117 (Pt 7): 1201-10. doi:10.1242/jcs.01058. PMID 14996942. 
  • Frieden M, James D, Castelbou C, et al. (2004). "Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1.". J. Biol. Chem. 279 (21): 22704-14. doi:10.1074/jbc.M312366200. PMID 15024001. 
  • Lee YJ, Jeong SY, Karbowski M, et al. (2005). "Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.". Mol. Biol. Cell 15 (11): 5001-11. doi:10.1091/mbc.E04-04-0294. PMID 15356267. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kong D, Xu L, Yu Y, et al. (2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1.". Mol. Cell. Biochem. 272 (1-2): 187-99. PMID 16010987. 
  • Koch A, Yoon Y, Bonekamp NA, et al. (2006). "A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells.". Mol. Biol. Cell 16 (11): 5077-86. doi:10.1091/mbc.E05-02-0159. PMID 16107562. 
  • Yu T, Fox RJ, Burwell LS, Yoon Y (2006). "Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1.". J. Cell. Sci. 118 (Pt 18): 4141-51. doi:10.1242/jcs.02537. PMID 16118244. 
  • Yoon YS, Yoon DS, Lim IK, et al. (2006). "Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1.". J. Cell. Physiol. 209 (2): 468-80. doi:10.1002/jcp.20753. PMID 16883569. 
  • Alirol E, James D, Huber D, et al. (2007). "The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis.". Mol. Biol. Cell 17 (11): 4593-605. doi:10.1091/mbc.E06-05-0377. PMID 16914522. 
  • Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis.". Exp. Cell Res. 313 (8): 1675-86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615. 
  • Lee S, Jeong SY, Lim WC, et al. (2007). "Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence.". J. Biol. Chem. 282 (31): 22977-83. doi:10.1074/jbc.M700679200. PMID 17545159. 
 This protein-related article is a stub. You can help Wikipedia by expanding it.