Fibrocyte

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Fibrocytes are the blood-borne cells with the ability to produce extracellular matrix. The cells express the hematopoietic cell surface markers CD34+, CD45+, as well as fibroblast markers such as collagen. In addition, fibrocytes express the class II major histocompatibility complex molecules and the costimulatory molecules.[1] These cell can migrate to wound sites, suggesting a role in wound healing.[2] There are several studies suggesting that fibrocytes mediate wound healing and fibrotic tissue repair.[3][4][5]

[edit] References

  1. ^ Chesney J, Bacher M, Bender A, Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6307-12.
  2. ^ Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol. 2001 Jun 15;166(12):7556-62.
  3. ^ Yang L, et al., Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest. 2002 Sep;82(9):1183-92.
  4. ^ Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 2003 Jul 1;171(1):380-9.
  5. ^ Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, Hogaboam C, Wilke CA, Toews GB. CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol. 2005 Mar;166(3):675-84.