FIBP

From Wikipedia, the free encyclopedia

Fibroblast growth factor (acidic) intracellular binding protein

Identifiers

FIBP; FGFIBP; FIBP-1

External IDs

OMIM: 608296 MGI: 1926233 HomoloGene: 3106

Gene ontology
Molecular Function:	• protein binding • fibroblast growth factor binding
Cellular Component:	• membrane fraction • nucleus • mitochondrion
Biological Process:	• fibroblast growth factor receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004214 (mRNA)
NP_004205 (protein)

NM_021438 (mRNA)
NP_067413 (protein)

Location

Chr 11: 65.41 - 65.41 Mb

Chr 19: 5.46 - 5.47 Mb

Pubmed search

[1]

[2]

Fibroblast growth factor (acidic) intracellular binding protein, also known as FIBP, is a human gene.^[1]

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kolpakova E, Wiedłocha A, Stenmark H, et al. (1999). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor.". Biochem. J. 336 ( Pt 1): 213–22. PMID 9806903.
Kolpakova E, Frengen E, Stokke T, Olsnes S (2001). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein.". Biochem. J. 352 Pt 3: 629–35. PMID 11104667.
Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.". EMBO J. 21 (15): 4058–69. PMID 12145206.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.