FHIT

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Fragile histidine triad gene
PDB rendering based on 1fhi.
Available structures: 1fhi, 1fit, 2fhi, 2fit, 3fit, 4fit, 5fit, 6fit
Identifiers
Symbol(s)	FHIT; AP3Aase; FRA3B
External IDs	OMIM: 601153 MGI: 1277947 HomoloGene: 36307
Gene ontology Molecular Function: • magnesium ion binding • hydrolase activity • manganese ion binding • bis(5'-adenosyl)-triphosphatase activity Cellular Component: • cytoplasm Biological Process: • DNA replication • cell cycle • nucleotide metabolic process • negative regulation of progression through cell cycle
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2272	14198
Ensembl	ENSG00000189283	ENSMUSG00000060579
Uniprot	P49789	Q91Y56
Refseq	NM_002012 (mRNA) NP_002003 (protein)	NM_010210 (mRNA) NP_034340 (protein)
Location	Chr 3: 59.71 - 60.5 Mb	Chr 14: 8.37 - 9.22 Mb
Pubmed search	[1]	[2]

Fragile histidine triad gene, also known as FHIT, is a human gene.

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.^[1]

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