FGR (gene)

From Wikipedia, the free encyclopedia

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

Identifiers

FGR; FLJ43153; MGC75096; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr

External IDs

OMIM: 164940 MGI: 95527 HomoloGene: 3842

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042729 (mRNA)
NP_001036194 (protein)

NM_010208 (mRNA)
NP_034338 (protein)

Location

Chr 1: 27.81 - 27.83 Mb

Chr 4: 132.25 - 132.27 Mb

Pubmed search

[1]

[2]

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a human gene.^[1]

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog.

[edit] Further reading

Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages.". Pathobiology 59 (4): 289–92. PMID 1652975.
Resh MD (1994). "Myristylation and palmitylation of Src family members: the fats of the matter.". Cell 76 (3): 411–3. PMID 8313462.
Lowell CA, Berton G (1999). "Integrin signal transduction in myeloid leukocytes.". J. Leukoc. Biol. 65 (3): 313–20. PMID 10080533.
Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.". Annu. Rev. Immunol. 17: 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777.
Tatosyan AG, Mizenina OA (2000). "Kinases of the Src family: structure and functions.". Biochemistry Mosc. 65 (1): 49–58. PMID 10702640.
Patel MS, Mankoo BS, Brickell PM (1993). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1.". Hum. Mol. Genet. 1 (1): 65. PMID 1339476.
Link DC, Gutkind SJ, Robbins KC, Ley TJ (1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.". Oncogene 7 (5): 877–84. PMID 1373875.
Patel M, Leevers SJ, Brickell PM (1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites.". Oncogene 5 (2): 201–6. PMID 1690869.
Biondi A, Paganin C, Rossi V, et al. (1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells.". Eur. J. Immunol. 21 (3): 843–6. PMID 1826268.
Gutkind JS, Link DC, Katamine S, et al. (1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.". Mol. Cell. Biol. 11 (3): 1500–7. PMID 1847500.
Patel M, Leevers SJ, Brickell PM (1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines.". Int. J. Cancer 45 (2): 342–6. PMID 2154410.
Parker RC, Mardon G, Lebo RV, et al. (1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20.". Mol. Cell. Biol. 5 (4): 831–8. PMID 2581127.
Brickell PM, Patel M (1989). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines.". Br. J. Cancer 58 (6): 704–9. PMID 2852026.
Tronick SR, Popescu NC, Cheah MS, et al. (1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family.". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. PMID 2995972.
Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection.". Nature 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578.
Nishizawa M, Semba K, Yoshida MC, et al. (1987). "Structure, expression, and chromosomal location of the human c-fgr gene.". Mol. Cell. Biol. 6 (2): 511–7. PMID 3023853.
Katamine S, Notario V, Rao CD, et al. (1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr.". Mol. Cell. Biol. 8 (1): 259–66. PMID 3275868.
Inoue K, Ikawa S, Semba K, et al. (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.". Oncogene 1 (3): 301–4. PMID 3330776.
Nishizawa M, Semba K, Yamamoto T, Toyoshima K (1985). "Human c-f gr gene does not contain coding sequence for actin-like protein.". Jpn. J. Cancer Res. 76 (3): 155–9. PMID 3922831.