FGL2

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Fibrinogen-like 2
Identifiers
Symbol(s) FGL2; T49; pT49
External IDs OMIM: 605351 MGI: 103266 HomoloGene: 4864
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10875 14190
Ensembl ENSG00000127951 ENSMUSG00000039899
Uniprot Q14314 Q544K3
Refseq NM_006682 (mRNA)
NP_006673 (protein)		 NM_008013 (mRNA)
NP_032039 (protein)
Location Chr 7: 76.66 - 76.67 Mb Chr 5: 20.88 - 20.89 Mb
Pubmed search [1] [2]

Fibrinogen-like 2, also known as FGL2, is a human gene.[1]

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.[1]

[edit] References

  1. ^ a b Entrez Gene: FGL2 fibrinogen-like 2.

[edit] Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151. 
  • Rüegg C, Pytela R (1995). "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein.". Gene 160 (2): 257–62. PMID 7642106. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Marazzi S, Blum S, Hartmann R, et al. (1998). "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes.". J. Immunol. 161 (1): 138–47. PMID 9647217. 
  • Yuwaraj S, Ding J, Liu M, et al. (2001). "Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant.". Genomics 71 (3): 330–8. doi:10.1006/geno.2000.6444. PMID 11170750. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart.". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ning Q, Sun Y, Han M, et al. (2005). "Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection.". J. Immunol. 174 (11): 7403–11. PMID 15905589. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Zhu CL, Yan WM, Zhu F, et al. (2006). "Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B.". World J. Gastroenterol. 11 (44): 6936–40. PMID 16437596. 
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