FGL1

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Fibrinogen-like 1
Identifiers
Symbol(s) FGL1; HFREP1; HP-041; LFIRE1; MGC12455
External IDs OMIM: 605776 MGI: 102795 HomoloGene: 37927
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2267 234199
Ensembl ENSG00000104760 ENSMUSG00000031594
Uniprot Q08830 n/a
Refseq XM_001129317 (mRNA)
XP_001129317 (protein)		 NM_145594 (mRNA)
NP_663569 (protein)
Location Chr 8: 17.77 - 17.8 Mb Chr 8: 42.69 - 42.71 Mb
Pubmed search [1] [2]

Fibrinogen-like 1, also known as FGL1, is a human gene.[1]

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: FGL1 fibrinogen-like 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Yamamoto T, Gotoh M, Sasaki H, et al. (1993). "Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1.". Biochem. Biophys. Res. Commun. 193 (2): 681-7. doi:10.1006/bbrc.1993.1678. PMID 8390249. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Hara H, Yoshimura H, Uchida S, et al. (2001). "Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity.". Biochim. Biophys. Acta 1520 (1): 45-53. PMID 11470158. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart.". J. Hum. Genet. 48 (3): 159-62. doi:10.1007/s100380300025. PMID 12624729. 
  • Yan J, Yu Y, Wang N, et al. (2004). "LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma.". Oncogene 23 (10): 1939-49. doi:10.1038/sj.onc.1207306. PMID 14981537. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Rijken DC, Dirkx SP, Luider TM, Leebeek FW (2006). "Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot.". Biochem. Biophys. Res. Commun. 350 (1): 191-4. doi:10.1016/j.bbrc.2006.09.018. PMID 16996032. 
  • Liu Z, Ukomadu C (2008). "Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant.". Biochem. Biophys. Res. Commun. 365 (4): 729-34. doi:10.1016/j.bbrc.2007.11.069. PMID 18039467. 
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