FGD3

From Wikipedia, the free encyclopedia

FYVE, RhoGEF and PH domain containing 3

PDB rendering based on 2coc.

Available structures: 2coc

Identifiers

Symbol(s)

FGD3; FLJ00004; MGC117260; ZFYVE5

External IDs

MGI: 1353657 HomoloGene: 22925

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding • zinc ion binding • small GTPase binding • metal ion binding
Cellular Component:	• ruffle • intracellular • cytoplasm • Golgi apparatus • cytoskeleton • lamellipodium
Biological Process:	• cytoskeleton organization and biogenesis • regulation of cell shape • actin cytoskeleton organization and biogenesis • regulation of Rho protein signal transduction • regulation of Cdc42 GTPase activity • filopodium formation

Orthologs

Human

Mouse

Refseq

NM_033086 (mRNA)
NP_149077 (protein)

NM_015759 (mRNA)
NP_056574 (protein)

Location

Chr 9: 94.75 - 94.84 Mb

Chr 13: 49.28 - 49.32 Mb

Pubmed search

[1]

[2]

FYVE, RhoGEF and PH domain containing 3, also known as FGD3, is a human gene.^[1]

[edit] References

^ Entrez Gene: FGD3 FYVE, RhoGEF and PH domain containing 3.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Pasteris NG, Nagata K, Hall A, Gorski JL (2000). "Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue.". Gene 242 (1-2): 237-47. PMID 10721717.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357-66. PMID 11214971.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.". Am. J. Hum. Genet. 81 (1): 1-16. doi:10.1086/518428. PMID 17564959.