FEZ2

From Wikipedia, the free encyclopedia

Fasciculation and elongation protein zeta 2 (zygin II)

Identifiers

FEZ2; HUM3CL; MGC117372

External IDs

OMIM: 604826 MGI: 2675856 HomoloGene: 3742

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cellular_component
Biological Process:	• signal transduction • nervous system development • axon guidance • hemopoiesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042548 (mRNA)
NP_001036013 (protein)

XM_982139 (mRNA)
XP_987233 (protein)

Location

Chr 2: 36.63 - 36.68 Mb

Chr 17: 78.28 - 78.32 Mb

Pubmed search

[1]

[2]

Fasciculation and elongation protein zeta 2 (zygin II), also known as FEZ2, is a human gene.^[1]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.^[1]

[edit] References

^ ^a ^b Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II).

[edit] Further reading

Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes.". J. Immunol. 151 (10): 5810–21. PMID 8228263.
Bloom L, Horvitz HR (1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3414–9. PMID 9096408.
Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.". Mech. Dev. 90 (2): 181–93. PMID 10642437.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Fujita T, Ikuta J, Hamada J, et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.". Biochem. Biophys. Res. Commun. 313 (3): 738–44. PMID 14697253.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.