FEZ1

From Wikipedia, the free encyclopedia

Fasciculation and elongation protein zeta 1 (zygin I)

Identifiers

External IDs

OMIM: 604825 MGI: 2670976 HomoloGene: 21063

Gene ontology
Molecular Function:	• protein binding • gamma-tubulin binding
Cellular Component:	• cytoplasm • centrosome
Biological Process:	• cell adhesion • nervous system development • axon guidance

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005103 (mRNA)
NP_005094 (protein)

NM_183171 (mRNA)
NP_898994 (protein)

Location

Chr 11: 124.82 - 124.87 Mb

Chr 9: 36.58 - 36.64 Mb

Pubmed search

[1]

[2]

Fasciculation and elongation protein zeta 1 (zygin I), also known as FEZ1, is a human gene.^[1]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I).

[edit] Further reading

Bloom L, Horvitz HR (1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3414–9. PMID 9096408.
Kuroda S, Nakagawa N, Tokunaga C, et al. (1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.". J. Cell Biol. 144 (3): 403–11. PMID 9971736.
Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.". Eur. J. Biochem. 269 (2): 538–45. PMID 11856312.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Miyoshi K, Honda A, Baba K, et al. (2004). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.". Mol. Psychiatry 8 (7): 685–94. doi:10.1038/sj.mp.4001352. PMID 12874605.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.". J. Biol. Chem. 279 (51): 53533–43. doi:10.1074/jbc.M402916200. PMID 15466860.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yamada K, Nakamura K, Minabe Y, et al. (2005). "Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts.". Biol. Psychiatry 56 (9): 683–90. doi:10.1016/j.biopsych.2004.08.015. PMID 15522253.
Suzuki T, Okada Y, Semba S, et al. (2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation.". J. Biol. Chem. 280 (26): 24948–56. doi:10.1074/jbc.M411499200. PMID 15843383.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.
Blasius TL, Cai D, Jih GT, et al. (2007). "Two binding partners cooperate to activate the molecular motor Kinesin-1.". J. Cell Biol. 176 (1): 11–7. doi:10.1083/jcb.200605099. PMID 17200414.
Koga M, Ishiguro H, Horiuchi Y, et al. (2007). "Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population.". Neurosci. Lett. 417 (3): 326–9. doi:10.1016/j.neulet.2007.02.055. PMID 17374448.