Phycocyanobilin:ferredoxin oxidoreductase

From Wikipedia, the free encyclopedia

In enzymology, a phycocyanobilin:ferredoxin oxidoreductase (EC 1.3.7.5) is an enzyme that catalyzes the chemical reaction

(3Z)-phycocyanobilin + oxidized ferredoxin $\rightleftharpoons$ biliverdin IXalpha + reduced ferredoxin

Thus, the two substrates of this enzyme are (3Z)-phycocyanobilin and oxidized ferredoxin, whereas its two products are biliverdin IXalpha and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is (3Z)-phycocyanobilin:ferredoxin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D1E, 2DKE, and 2G18.

[edit] References

IUBMB entry for 1.3.7.5
BRENDA references for 1.3.7.5 (Recommended.)
PubMed references for 1.3.7.5
PubMed Central references for 1.3.7.5
Google Scholar references for 1.3.7.5
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC (2001). "Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms". Plant. Cell. 13: 965–78. PMID 11283349.
Beale SI (1993). "Biosynthesis of phycobilins". Chem. Rev. 93: 785–802.
Wu SH, McDowell MT, Lagarias JC (1997). "Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum". J. Biol. Chem. 272: 25700–5. PMID 9325294.