Ferredoxin-NADP+ reductase

From Wikipedia, the free encyclopedia

In enzymology, a ferredoxin---NADP+ reductase (EC 1.18.1.2) is an enzyme that catalyzes the chemical reaction

2 reduced ferredoxin + NADP⁺ + H⁺ 2 oxidized ferredoxin + NADPH

The 3 substrates of this enzyme are reduced ferredoxin, NADP⁺, and H⁺, whereas its two products are oxidized ferredoxin and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ferredoxin:NADP+ oxidoreductase. Other names in common use include adrenodoxin reductase, ferredoxin-nicotinamide adenine dinucleotide phosphate reductase, ferredoxin-NADP+ reductase, TPNH-ferredoxin reductase, ferredoxin-NADP+ oxidoreductase, NADP+:ferredoxin oxidoreductase, ferredoxin-TPN reductase, reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin, reductase, ferredoxin-NADP+-oxidoreductase, NADPH:ferredoxin oxidoreductase, ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized), reductase, and ferredoxin---NADP+ reductase. This enzyme participates in photosynthesis. It has 2 cofactors: FAD, and Flavin.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 54 structures have been solved for this class of enzymes, with PDB accession codes 1B2R, 1BJK, 1BQE, 1BX0, 1BX1, 1CJC, 1E1L, 1E62, 1E63, 1E64, 1E6E, 1EWY, 1FDR, 1FNB, 1FNC, 1FND, 1FRN, 1FRQ, 1GAQ, 1GAW, 1GJR, 1GO2, 1GR1, 1H42, 1H85, 1JB9, 1OGI, 1OGJ, 1QFY, 1QFZ, 1QG0, 1QGA, 1QGY, 1QGZ, 1QH0, 1QUE, 1QUF, 1SM4, 1W34, 1W35, 1W87, 2B5O, 2BGI, 2BGJ, 2BMW, 2BSA, 2C7G, 2GQW, 2GR0, 2GR1, 2GR2, 2GR3, 2OK7, and 2OK8.

[edit] References

• IUBMB entry for 1.18.1.2
• BRENDA references for 1.18.1.2 (Recommended.)
• PubMed references for 1.18.1.2
• PubMed Central references for 1.18.1.2
• Google Scholar references for 1.18.1.2
• O (1966). "Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase". Arch. Biochem. Biophys. 117: 660–673. 
• Shin M, Tagawa K and Arnon DI (1963). "Crystallization of ferredoxin-TPN reductase and its role in the photosynthetic apparatus of chloroplasts". Biochem. Z. 338: 84–96. 

[edit] External links

The CAS registry number for this enzyme class is 9029-33-8.

• IUBMB entry for 1.18.1.2

• KEGG entry for 1.18.1.2

• BRENDA entry for 1.18.1.2

• NiceZyme view of 1.18.1.2

• EC2PDB: PDB structures for 1.18.1.2

• PRIAM entry for 1.18.1.2

• PUMA2 entry for 1.18.1.2

• IntEnz: Integrated Enzyme entry for 1.18.1.2

• MetaCyc entry for 1.18.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004324: ferredoxin-NADP+ reductase

• AMIGO entry for GO code 0004324: ferredoxin-NADP+ reductase