Ferredoxin-NAD+ reductase

From Wikipedia, the free encyclopedia

In enzymology, a ferredoxin---NAD+ reductase (EC 1.18.1.3) is an enzyme that catalyzes the chemical reaction

reduced ferredoxin + NAD⁺ oxidized ferredoxin + NADH + H⁺

Thus, the two substrates of this enzyme are reduced ferredoxin and NAD⁺, whereas its 3 products are oxidized ferredoxin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ferredoxin:NAD+ oxidoreductase. Other names in common use include ferredoxin-nicotinamide adenine dinucleotide reductase, ferredoxin reductase, NAD+-ferredoxin reductase, NADH-ferredoxin oxidoreductase, reductase, reduced nicotinamide adenine dinucleotide-ferredoxin, ferredoxin-NAD+ reductase, NADH-ferredoxin reductase, NADH2-ferredoxin oxidoreductase, NADH flavodoxin oxidoreductase, NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase, multicomponent enzyme system), ferredoxin-linked NAD+ reductase, NADH-ferredoxinTOL reductase (component of toluene dioxygenase), and ferredoxin---NAD reductase. This enzyme participates in fatty acid metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1KRH.

[edit] References

• IUBMB entry for 1.18.1.3
• BRENDA references for 1.18.1.3 (Recommended.)
• PubMed references for 1.18.1.3
• PubMed Central references for 1.18.1.3
• Google Scholar references for 1.18.1.3
• Jungermann K, Thauer RK, Leimenstoll G, Decker K (1973). "Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia". Biochim. Biophys. Acta. 305: 268–80. PMID 4147457. 

[edit] External links

The CAS registry number for this enzyme class is 39369-37-4.

• IUBMB entry for 1.18.1.3

• KEGG entry for 1.18.1.3

• BRENDA entry for 1.18.1.3

• NiceZyme view of 1.18.1.3

• EC2PDB: PDB structures for 1.18.1.3

• PRIAM entry for 1.18.1.3

• PUMA2 entry for 1.18.1.3

• IntEnz: Integrated Enzyme entry for 1.18.1.3

• MetaCyc entry for 1.18.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008860: ferredoxin-NAD+ reductase

• AMIGO entry for GO code 0008860: ferredoxin-NAD+ reductase