Feline sarcoma oncogene

From Wikipedia, the free encyclopedia

PDB rendering based on 1wqu.

Available structures: 1wqu, 2dcr

Identifiers

Symbol(s)

FES; FPS

External IDs

OMIM: 190030 MGI: 95514 HomoloGene: 37563

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002005 (mRNA)
NP_001996 (protein)

XM_981464 (mRNA)
XP_986558 (protein)

Location

Chr 15: 89.23 - 89.24 Mb

Chr 7: 80.25 - 80.26 Mb

Pubmed search

[1]

[2]

Feline sarcoma oncogene, also known as FES, is a human gene.^[1]

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: FES feline sarcoma oncogene.

[edit] Further reading

Smithgall TE, Rogers JA, Peters KL, et al. (1998). "The c-Fes family of protein-tyrosine kinases.". Critical reviews in oncogenesis 9 (1): 43–62. PMID 9754447.
Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136.
Greer P (2002). "Closing in on the biological functions of Fps/Fes and Fer.". Nat. Rev. Mol. Cell Biol. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.