Wikipedia:Featured picture candidates/citric acid cycle

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[edit] Citric Acid Cycle

Reason

It's pretty much the best visual aid for the citric acid cycle article. It's color coded, comprehensive, and easy to follow. There's also a .svg version of this image on the Wikimedia Commons if anyone wants to nominate that as an alternative. The link to it is on the page of the image. I don't know how to port the .svg file into Wikipedia.

Proposed caption

The citric acid cycle is a series of enzymatic reactions carried out inside the inner membranes of the cell's mitochondria. The process begins when the two-carbon acetyl CoA enters the cycle and joins the four-carbon oxaloacetate to produce the six-carbon citrate. For each turn of the eight-step cycle, three molecules of NADH and one molecule each of FADH2 and GTP are produced, and two molecules of carbon dioxide are released as by-products. NADH and FADH2 are high energy electron carrier molecules that will later fuel the electron transport chain during oxidative phosphorylation, which produces ATP, the cell's primary source of energy. GTP may be converted to ATP in a separate process or used for other cell activities. The product in the final step of the cycle, oxaloacetate, is recycled and combined with a new molecule of acetyl CoA to produce citrate, restarting the cycle.

Articles this image appears in

citric acid cycle

Creator

YassineMrabet

• Support as nominator AutoGyro 00:11, 8 October 2007 (UTC)
• Support nice clean biochem. Shows the atoms, which is nice. The "see text" blurb could cut out. Debivort 02:22, 8 October 2007 (UTC)

• Oppose SVG doesn't render right lots of stray white and black boxes. bleh. Debivort 04:27, 8 October 2007 (UTC)

• Support edit 1 Debivort 21:43, 8 October 2007 (UTC)

• Comment, "see text" needs to be cut out and I think this could be bigger... gren グレン 03:37, 8 October 2007 (UTC)
• Note to nominator: using a SVG image is exactly the same as using a raster (PNG, GIF, JPEG) image. I have done the replacement. MER-C 03:48, 8 October 2007 (UTC)
• Oppose First, there seem to be some weird artifacts, like black and white boxes showing up over the diagram. I don't know what is going on with that. Another problem is with the label "a-cetoglutarate" which should be "α-ketoglutarate" (don't forget this occurs as an intermediate and as a name of the enzyme, fix in both places). There seems to be a few places where a caption is missing, such as the entry arrows near fumarase and aconitase, in two places. It is a good start, and a pretty nice drawing. I like the fact that we get skeleton structures by each of the intermediate names, but I don't like the way the legend looks, it looks way too "boxy" and dominant. I didn't have the chance to fact-check the whole diagram, but should be done. Good work so far but needs revision, and it is totally fixable. Jeff Dahl 04:24, 8 October 2007 (UTC)

Support Edit 1 with proposed revised caption With the changes the image looks much better. Only one concern, what are the orange circles that show up behind some of the bonds in the structures? If they are important, probably should explain. I suggest a minor rewording of the caption so the terms are more accurate: Jeff Dahl 21:25, 8 October 2007 (UTC)

Proposed revised captionThe citric acid cycle is a set of enzymatic reactions carried out inside the membranes of the cell's mitochondria. The two-carbon acetyl CoA enters the cycle and joins the four-carbon oxaloacetate to produce the six-carbon citrate. Three molecules of NADH and one molecule each of FADH2 and GTP are produced for each acetyl CoA entering the cycle. FADH2 and GTP are high energy electron carrier molecules that the body uses to make ATP, the cell's primary source of energy. The product in the final step, oxaloacetate, is recycled and combined with a new molecule of acetyl CoA, restarting the cycle.

Proposed revised caption 2 The citric acid cycle is a set of enzymatic reactions carried out inside the membranes of the cell's mitochondria. The two-carbon acetyl CoA enters the cycle and joins the four-carbon oxaloacetate to produce the six-carbon citrate. For each turn of the eight-step cycle, three molecules of NADH and one molecule each of FADH2 and GTP are produced. NADH and FADH2 are high energy electron carrier molecules that will late fuel the electron transport chain during oxidative phosphorylation, which produces ATP, the cell's primary source of energy. GTP is converted to ATP in a separate process. The product in the final step of the cycle, oxaloacetate, is recycled and combined with a new molecule of acetyl CoA to produce citrate, restarting the cycle.

Comment: GTP is not necessarily converted to ATP, it is used to provide energy for protein synthesis and is utilized by G proteins. That sentence should be removed. Sakkura 06:48, 11 October 2007 (UTC)

--AutoGyro 21:39, 8 October 2007 (UTC)

• revised caption 2 looks good to me. I assume you mean "later" instead of "late"? :) Jeff Dahl 02:28, 9 October 2007 (UTC)

Artifacts? I don't think those are artifacts . . . IvoShandor 07:20, 8 October 2007 (UTC)

• Comment I see four black boxes randomly scattered over the diagram. As for the presentation of the image: I admit I have no knowledge what the diagram represents, but it looks very "clean" and encyclopedic. If the issues are fixed I'd support easily. – sgeureka ^t•c 11:12, 8 October 2007 (UTC)
  • Support edit 1 since issues seem to got fixed. – sgeureka ^t•c 17:48, 8 October 2007 (UTC)
• Comment I only see the black boxes on the SVG version; they weren't there on the PNG that was originally nommed. SVG files just don't show up properly for me (Windows XP, Firefox 2), which I why I find their use so irritating. It's been too long since grade 13 biology for me to comment on the accuracy, but I do like this setup. As with user Jeff Dahl's comment, I also find the legend a bit too boxy (thinner lines to outline, I think), but that's not a big deal. Easy support if the details are worked out by people more familiar with the process. Matt Deres 15:24, 8 October 2007 (UTC)
• Strong support edit 1 - Super enc., and a lot of good work. I think the SVG is fine, but that the rsvg renderer that Firefox and Wikipedia use is buggy. I have made some fixes per above, and uploaded both the SVG and a PNG version. The PNG version points to the SVG and says "replace when the SVG version is better", which will presumably happen one day when SVG renderers stop sucking. It's super-important to maintain the SVG for editability. I made the following fixes:

• Remove "see text"
• De-emphasize legend's box
• Fix speling to α-ketoglutarate
• The other problems (missing captions, stray boxes) were rendering problems

--Sean 16:24, 8 October 2007 (UTC)

• Also, I support whatever improved caption the brainiacs above hash out. They look really solid. As for the orange blobs, I think they indicate where some action is going to happen in the next step. Compare the blue highlighting in this version. I dunno, though, as I don't think I'd heard the phrase "Krebs cycle" since 1989! --Sean 01:31, 9 October 2007 (UTC)

• Support SVG edit 1 Looks great now. High enc (over my head).--HereToHelp 23:35, 8 October 2007 (UTC)
• Oppose. The SVG is hopelessly broken and the PNG looks really nasty- the colors leak out from their black borders and the text is blurry --froth^t 01:55, 10 October 2007 (UTC)

comment were you looking at the edited version? That one doesn't have rendering issues.--AutoGyro 02:19, 10 October 2007 (UTC)

comment Huh? The PNG looks great. Could you clarify which text is blurry, and where color is leaking out from the black borders? If you google for citric acid cycle you'll see that this image is *vastly* better than anything else out there. It's extremely informative and makes a daunting and extremely encyclopedic topic very clear. --Sean 19:01, 10 October 2007 (UTC)

• Oppose. There is a non-trivial error in the diagram: citrate synthetase should be citrate synthase. More trivially, the i in Pi should be subscript (which it doesn't appear to be currently). --Sakkura 05:56, 11 October 2007 (UTC)

• "Synthetase appears to be acceptable. Debivort 06:46, 11 October 2007 (UTC)

A synthetase is a different type of enzyme than a synthase. Quoted from the ligase article: "Note that "synthetase" should not be confused with synthases, as synthases do not use adenosine triphosphate and belong to the lyase group, while synthetases do use adenosine triphosphate (ATP)." Sakkura 06:52, 11 October 2007 (UTC)

Ah. thanks for the explanation. Debivort 18:43, 11 October 2007 (UTC)

• I have changed citrate synthetase to citrate synthase in one place, and fixed P_i in two places (edit 2). --Sean 14:40, 11 October 2007 (UTC)
• Support edit 2. Everything seems to be in order now. Sakkura 17:15, 11 October 2007 (UTC)

• Great! Thanks for the informed criticism. --Sean 19:02, 11 October 2007 (UTC)

Promoted Image:Citricacidcycle ball2.png MER-C 07:37, 15 October 2007 (UTC)