FDXR

From Wikipedia, the free encyclopedia

Ferredoxin reductase

Identifiers

FDXR; ADXR

External IDs

OMIM: 103270 MGI: 104724 HomoloGene: 3033

Gene ontology
Molecular Function:	• ferredoxin-NADP+ reductase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial inner membrane
Biological Process:	• electron transport • lipid metabolic process • steroid biosynthetic process • transport • cholesterol metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004110 (mRNA)
NP_004101 (protein)

XM_991496 (mRNA)
XP_996590 (protein)

Location

Chr 17: 70.37 - 70.38 Mb

Chr 11: 115.08 - 115.09 Mb

Pubmed search

[1]

[2]

Ferredoxin reductase, also known as FDXR, is a human gene.^[1]

This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: FDXR ferredoxin reductase.

[edit] Further reading

Sparkes RS, Klisak I, Miller WL (1991). "Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25.". DNA Cell Biol. 10 (5): 359–65. PMID 1863359.
Coghlan VM, Vickery LE (1991). "Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc.". J. Biol. Chem. 266 (28): 18606–12. PMID 1917982.
Lin D, Shi YF, Miller WL (1990). "Cloning and sequence of the human adrenodoxin reductase gene.". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8516–20. PMID 2236061.
Usanov SA, Chernogolov AA, Honkakoski P, et al. (1990). "[Cholesterol-hydroxylating cytochrome P-450 from bovine adrenal cortex mitochondria and human placenta: immunochemical properties and structural characteristics]". Biokhimiia 55 (5): 865–77. PMID 2393675.
Sasano H, Sasano N, Okamoto M, Nonaka Y (1989). "Immunohistochemical demonstration of adrenodoxin reductase in bovine and human adrenals.". Pathol. Res. Pract. 184 (5): 473–9. PMID 2748461.
Usanov SA, Honkakoski P, Lang MA, et al. (1989). "Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme complex.". Biochim. Biophys. Acta 998 (2): 189–95. PMID 2790061.
Solish SB, Picado-Leonard J, Morel Y, et al. (1988). "Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7104–8. PMID 2845396.
Mittal S, Zhu YZ, Vickery LE (1988). "Molecular cloning and sequence analysis of human placental ferredoxin.". Arch. Biochem. Biophys. 264 (2): 383–91. PMID 2969697.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Müller JJ, Lapko A, Bourenkov G, et al. (2001). "Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis.". J. Biol. Chem. 276 (4): 2786–9. doi:10.1074/jbc.M008501200. PMID 11053423.
Gonzalez MI, Robins DM (2001). "Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1.". J. Biol. Chem. 276 (9): 6420–8. doi:10.1074/jbc.M008689200. PMID 11096094.
Tuckey RC, Headlam MJ (2002). "Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase.". J. Steroid Biochem. Mol. Biol. 81 (2): 153–8. PMID 12137805.
Liu G, Chen X (2002). "The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis.". Oncogene 21 (47): 7195–204. doi:10.1038/sj.onc.1205862. PMID 12370809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Araya Z, Hosseinpour F, Bodin K, Wikvall K (2003). "Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1.". Biochim. Biophys. Acta 1632 (1-3): 40–7. PMID 12782149.
Thiboutot D, Jabara S, McAllister JM, et al. (2003). "Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1).". J. Invest. Dermatol. 120 (6): 905–14. doi:10.1046/j.1523-1747.2003.12244.x. PMID 12787114.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.