FCRLA

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Fc receptor-like A
Identifiers
Symbol(s) FCRLA; FCRL; FCRLM1; FCRLX; FCRLb; FCRLc1; FCRLc2; FCRLd; FCRLe; FREB; MGC4595; RP11-474I16.5
External IDs OMIM: 606891 MGI: 2138647 HomoloGene: 13106
Orthologs
Human Mouse
Entrez 84824 98752
Ensembl ENSG00000132185 ENSMUSG00000038421
Uniprot Q7L513 Q920A9
Refseq NM_032738 (mRNA)
NP_116127 (protein)		 NM_145141 (mRNA)
NP_660123 (protein)
Location Chr 1: 159.94 - 159.95 Mb Chr 1: 172.75 - 172.76 Mb
Pubmed search [1] [2]

Fc receptor-like A, also known as FCRLA, is a human gene.[1]

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: FCRLA Fc receptor-like A.

[edit] Further reading

  • Mechetina LV, Najakshin AM, Volkova OY, et al. (2002). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.". Eur. J. Immunol. 32 (1): 87–96. PMID 11754007. 
  • Facchetti F, Cella M, Festa S, et al. (2002). "An unusual Fc receptor-related protein expressed in human centroblasts.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3776–81. doi:10.1073/pnas.022042699. PMID 11891275. 
  • Davis RS, Li H, Chen CC, et al. (2003). "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.". Int. Immunol. 14 (9): 1075–83. PMID 12202404. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Huizinga TW, Ioan-Facsinay A (2004). "Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways.". J. Rheumatol. 30 (9): 1904–6. PMID 12966588. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Inozume T, Matsuzaki Y, Kurihara S, et al. (2005). "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients.". Int. J. Cancer 114 (2): 283–90. doi:10.1002/ijc.20735. PMID 15551350. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.". Immunogenetics 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841. 
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