FCRL3

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Fc receptor-like 3
Identifiers
Symbol(s) FCRL3; FCRH3; IFGP3; IRTA3; SPAP2
External IDs OMIM: 606510 MGI: 3053558 HomoloGene: 76447
Orthologs
Human Mouse
Entrez 115352 329693
Ensembl ENSG00000160856 ENSMUSG00000048031
Refseq NM_001024667 (mRNA)
NP_001019838 (protein)		 NM_183222 (mRNA)
NP_899045 (protein)
Location Chr 1: 155.91 - 155.94 Mb Chr 3: 87.52 - 87.54 Mb
Pubmed search [1] [2]

Fc receptor-like 3, also known as FCRL3, is a human gene.[1]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[1]

[edit] References

  1. ^ a b Entrez Gene: FCRL3 Fc receptor-like 3.

[edit] Further reading

  • Davis RS, Dennis G, Kubagawa H, Cooper MD (2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family.". Curr. Top. Microbiol. Immunol. 266: 85–112. PMID 12014205. 
  • Davis RS, Wang YH, Kubagawa H, Cooper MD (2001). "Identification of a family of Fc receptor homologs with preferential B cell expression.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMID 11493702. 
  • Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.". Blood 99 (8): 2662–9. PMID 11929751. 
  • Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs.". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kochi Y, Yamada R, Suzuki A, et al. (2005). "A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMID 15838509. 
  • Simmonds MJ, Heward JM, Carr-Smith J, et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851. 
  • Eyre S, Bowes J, Potter C, et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Res. Ther. 8 (4): R117. doi:10.1186/ar2006. PMID 16859508. 
  • Umemura T, Ota M, Yoshizawa K, et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis.". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. PMID 17020818. 
  • Schäfer N, Blaumeiser B, Becker T, et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata.". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947. 
  • Newman WG, Zhang Q, Liu X, et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579. 
  • Choi CB, Kang CP, Seong SS, et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans.". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581. 
  • Owen CJ, Kelly H, Eden JA, et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association.". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162. 
  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.". Immunogenetics 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841. 
  • Martínez A, Núñez C, Martín MC, et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.". Tissue Antigens 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014. 
  • Martínez A, Mas A, de Las Heras V, et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1-2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473. 
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