FCGRT

From Wikipedia, the free encyclopedia

Fc fragment of IgG, receptor, transporter, alpha

PDB rendering based on 1exu.

Available structures: 1exu

Identifiers

Symbol(s)

FCGRT; FCRN; alpha-chain

External IDs

OMIM: 601437 MGI: 103017 HomoloGene: 3030

Gene ontology
Molecular Function:	• receptor activity • IgG binding
Cellular Component:	• membrane • integral to membrane • MHC class I protein complex
Biological Process:	• immune response • female pregnancy • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004107 (mRNA)
NP_004098 (protein)

NM_010189 (mRNA)
NP_034319 (protein)

Location

Chr 19: 54.71 - 54.72 Mb

Chr 7: 44.96 - 44.97 Mb

Pubmed search

[1]

[2]

Fc fragment of IgG, receptor, transporter, alpha, also known as FCGRT, is a human gene.^[1]

[edit] References

^ Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha.

[edit] Further reading

Story CM, Mikulska JE, Simister NE (1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus.". J. Exp. Med. 180 (6): 2377–81. PMID 7964511.
Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro.". J. Leukoc. Biol. 55 (4): 545–51. PMID 8145026.
Kandil E, Egashira M, Miyoshi O, et al. (1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3.". Cytogenet. Cell Genet. 73 (1-2): 97–8. PMID 8646894.
Leach JL, Sedmak DD, Osborne JM, et al. (1996). "Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport.". J. Immunol. 157 (8): 3317–22. PMID 8871627.
Kivelä J, Parkkila S, Waheed A, et al. (1998). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum.". Clin. Chem. 43 (12): 2318–22. PMID 9439449.
Vaughn DE, Bjorkman PJ (1998). "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.". Structure 6 (1): 63–73. PMID 9493268.
West AP, Bjorkman PJ (2000). "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,).". Biochemistry 39 (32): 9698–708. PMID 10933786.
Mikulska JE, Pablo L, Canel J, Simister NE (2000). "Cloning and analysis of the gene encoding the human neonatal Fc receptor.". Eur. J. Immunogenet. 27 (4): 231–40. PMID 10998088.
Zhu X, Meng G, Dickinson BL, et al. (2001). "MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells.". J. Immunol. 166 (5): 3266–76. PMID 11207281.
Ober RJ, Radu CG, Ghetie V, Ward ES (2002). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies.". Int. Immunol. 13 (12): 1551–9. PMID 11717196.
Praetor A, Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn.". J. Cell. Sci. 115 (Pt 11): 2389–97. PMID 12006623.
Claypool SM, Dickinson BL, Yoshida M, et al. (2002). "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.". J. Biol. Chem. 277 (31): 28038–50. doi:10.1074/jbc.M202367200. PMID 12023961.
Praetor A, Jones RM, Wong WL, Hunziker W (2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG.". J. Mol. Biol. 321 (2): 277–84. PMID 12144784.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shah U, Dickinson BL, Blumberg RS, et al. (2003). "Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine.". Pediatr. Res. 53 (2): 295–301. PMID 12538789.
Chaudhury C, Mehnaz S, Robinson JM, et al. (2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.". J. Exp. Med. 197 (3): 315–22. PMID 12566415.
Schilling R, Ijaz S, Davidoff M, et al. (2003). "Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions.". J. Virol. 77 (16): 8882–92. PMID 12885906.
Zhou J, Johnson JE, Ghetie V, et al. (2003). "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.". J. Mol. Biol. 332 (4): 901–13. PMID 12972260.
Cianga P, Cianga C, Cozma L, et al. (2004). "The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland.". Hum. Immunol. 64 (12): 1152–9. PMID 14630397.
Ober RJ, Martinez C, Vaccaro C, et al. (2004). "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.". J. Immunol. 172 (4): 2021–9. PMID 14764666.