FBXW7

From Wikipedia, the free encyclopedia

F-box and WD repeat domain containing 7

PDB rendering based on 2ovp.

Available structures: 2ovp, 2ovq, 2ovr

Identifiers

Symbol(s)

FBXW7; AGO; CDC4; DKFZp686F23254; FBW7; FBX30; FBXW6; SEL-10; SEL10

External IDs

OMIM: 606278 MGI: 1354695 HomoloGene: 69520

Gene ontology
Molecular Function:	• transcription factor activity • protein binding
Cellular Component:	• nucleus • endoplasmic reticulum • Golgi apparatus
Biological Process:	• Notch signaling pathway • protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001013415 (mRNA)
NP_001013433 (protein)

NM_080428 (mRNA)
NP_536353 (protein)

Location

Chr 4: 153.46 - 153.68 Mb

Chr 3: 85.04 - 85.06 Mb

Pubmed search

[1]

[2]

F-box and WD repeat domain containing 7, also known as FBXW7, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXW7 F-box and WD repeat domain containing 7.

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Gupta-Rossi N, Le Bail O, Gonen H, et al. (2001). "Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.". J. Biol. Chem. 276 (37): 34371–8. doi:10.1074/jbc.M101343200. PMID 11425854.
Oberg C, Li J, Pauley A, et al. (2001). "The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.". J. Biol. Chem. 276 (38): 35847–53. doi:10.1074/jbc.M103992200. PMID 11461910.
Koepp DM, Schaefer LK, Ye X, et al. (2001). "Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.". Science 294 (5540): 173–7. doi:10.1126/science.1065203. PMID 11533444.
Moberg KH, Bell DW, Wahrer DC, et al. (2001). "Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.". Nature 413 (6853): 311–6. doi:10.1038/35095068. PMID 11565033.
Strohmaier H, Spruck CH, Kaiser P, et al. (2001). "Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.". Nature 413 (6853): 316–22. doi:10.1038/35095076. PMID 11565034.
Wu G, Lyapina S, Das I, et al. (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMID 11585921.
Spruck CH, Strohmaier H, Sangfelt O, et al. (2002). "hCDC4 gene mutations in endometrial cancer.". Cancer Res. 62 (16): 4535–9. PMID 12183400.
Li J, Pauley AM, Myers RL, et al. (2002). "SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.". J. Neurochem. 82 (6): 1540–8. PMID 12354302.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Staropoli JF, McDermott C, Martinat C, et al. (2003). "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.". Neuron 37 (5): 735–49. PMID 12628165.
Calhoun ES, Jones JB, Ashfaq R, et al. (2003). "BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.". Am. J. Pathol. 163 (4): 1255–60. PMID 14507635.
Welcker M, Singer J, Loeb KR, et al. (2003). "Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.". Mol. Cell 12 (2): 381–92. PMID 14536078.
Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.". Nature 426 (6962): 87–91. doi:10.1038/nature02082. PMID 14603323.
Cassia R, Moreno-Bueno G, Rodríguez-Perales S, et al. (2004). "Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma.". J. Pathol. 201 (4): 589–95. doi:10.1002/path.1474. PMID 14648662.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nateri AS, Riera-Sans L, Da Costa C, Behrens A (2004). "The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.". Science 303 (5662): 1374–8. doi:10.1126/science.1092880. PMID 14739463.