FBXW2

From Wikipedia, the free encyclopedia


F-box and WD repeat domain containing 2
Identifiers
Symbol(s) FBXW2; FBW2; Fwd2; MGC117371; Md6
External IDs OMIM: 609071 MGI: 1353435 HomoloGene: 8131
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26190 30050
Ensembl ENSG00000119402 ENSMUSG00000035949
Uniprot Q9UKT8 Q8BS25
Refseq NM_012164 (mRNA)
NP_036296 (protein)		 NM_013890 (mRNA)
NP_038918 (protein)
Location Chr 9: 122.57 - 122.6 Mb Chr 2: 34.63 - 34.66 Mb
Pubmed search [1] [2]

F-box and WD repeat domain containing 2, also known as FBXW2, is a human gene.[1]

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.[1]

[edit] References

  1. ^ a b Entrez Gene: FBXW2 F-box and WD repeat domain containing 2.

[edit] Further reading

  • Patton EE, Willems AR, Tyers M (1998). "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis.". Trends Genet. 14 (6): 236–43. PMID 9635407. 
  • Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  • Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  • Chiaur DS, Murthy S, Cenciarelli C, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.". Cytogenet. Cell Genet. 88 (3-4): 255–8. PMID 10828603. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.". Nature 426 (6962): 87–91. doi:10.1038/nature02082. PMID 14603323. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. doi:10.1073/pnas.0307700101. PMID 15070733. 
  • Yang CS, Yu C, Chuang HC, et al. (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system.". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
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