FBXW11

From Wikipedia, the free encyclopedia

F-box and WD repeat domain containing 11

Identifiers

FBXW11; BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos; KIAA0696

External IDs

OMIM: 605651 MGI: 2144023 HomoloGene: 76444

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• Wnt receptor signaling pathway • protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_012300 (mRNA)
NP_036432 (protein)

NM_134015 (mRNA)
NP_598776 (protein)

Location

Chr 5: 171.22 - 171.37 Mb

Chr 11: 32.54 - 32.65 Mb

Pubmed search

[1]

[2]

F-box and WD repeat domain containing 11, also known as FBXW11, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXW11 F-box and WD repeat domain containing 11.

[edit] Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Suzuki H, Chiba T, Suzuki T, et al. (2000). "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.". J. Biol. Chem. 275 (4): 2877-84. PMID 10644755.
Koike J, Sagara N, Kirikoshi H, et al. (2000). "Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1.". Biochem. Biophys. Res. Commun. 269 (1): 103-9. doi:10.1006/bbrc.2000.2241. PMID 10694485.
Bhatia N, Herter JR, Slaga TJ, et al. (2002). "Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB.". Oncogene 21 (10): 1501-9. doi:10.1038/sj.onc.1205311. PMID 11896578.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601-6. doi:10.1073/pnas.252646399. PMID 12481031.
Busino L, Donzelli M, Chiesa M, et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.". Nature 426 (6962): 87-91. doi:10.1038/nature02082. PMID 14603323.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419-24. doi:10.1073/pnas.0307700101. PMID 15070733.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Koolen DA, Herbergs J, Veltman JA, et al. (2006). "Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1.". J. Hum. Genet. 51 (8): 721-6. doi:10.1007/s10038-006-0010-8. PMID 16865294.
Butticaz C, Michielin O, Wyniger J, et al. (2007). "Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.". J. Virol. 81 (3): 1502-5. doi:10.1128/JVI.01711-06. PMID 17121803.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.