FBXW10

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F-box and WD repeat domain containing 10
Identifiers
Symbol(s) FBXW10; C17orf1; C17orf1A; Fbw10; HREP; SM25H2; SM2SH2
External IDs OMIM: 604596 MGI: 3052463 HomoloGene: 32757
Orthologs
Human Mouse
Entrez 10517 213980


Refseq NM_031456 (mRNA)
NP_113644 (protein)		 NM_001033669 (mRNA)
NP_001028841 (protein)
Pubmed search [1] [2]

F-box and WD repeat domain containing 10, also known as FBXW10, is a human gene.[1]

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: FBXW10 F-box and WD repeat domain containing 10.

[edit] Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573-80. doi:10.1101/gad.1255304. PMID 15520277. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
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