FBXO5

From Wikipedia, the free encyclopedia

F-box protein 5

Identifiers

FBXO5; EMI1; FBX5; Fbxo31

External IDs

OMIM: 606013 MGI: 1914391 HomoloGene: 8135

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm • spindle
Biological Process:	• mitotic metaphase • oocyte maturation • ubiquitin cycle • cell cycle • regulation of progression through mitotic cell cycle • cell division • negative regulation of ubiquitin ligase activity during mitotic cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012177 (mRNA)
NP_036309 (protein)

NM_025995 (mRNA)
NP_080271 (protein)

Location

Chr 6: 153.33 - 153.35 Mb

Chr 10: 4.54 - 4.55 Mb

Pubmed search

[1]

[2]

F-box protein 5, also known as FBXO5, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXO5 F-box protein 5.

[edit] Further reading

Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells.". Genomics 59 (2): 168-77. doi:10.1006/geno.1999.5855. PMID 10409428.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Chiaur DS, Murthy S, Cenciarelli C, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.". Cytogenet. Cell Genet. 88 (3-4): 255-8. PMID 10828603.
Reimann JD, Freed E, Hsu JY, et al. (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.". Cell 105 (5): 645-55. PMID 11389834.
Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs.". Nature 416 (6883): 850-4. doi:10.1038/416850a. PMID 11976684.
Hsu JY, Reimann JD, Sørensen CS, et al. (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).". Nat. Cell Biol. 4 (5): 358-66. doi:10.1038/ncb785. PMID 11988738.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380-4. PMID 12703993.
Margottin-Goguet F, Hsu JY, Loktev A, et al. (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.". Dev. Cell 4 (6): 813-26. PMID 12791267.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7937-42. doi:10.1073/pnas.0402442101. PMID 15148369.
Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.". Mol. Biol. Cell 15 (12): 5623-34. doi:10.1091/mbc.E04-07-0598. PMID 15469984.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Eldridge AG, Loktev AV, Hansen DV, et al. (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.". Cell 124 (2): 367-80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
Lehman NL, Verschuren EW, Hsu JY, et al. (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.". Cell Cycle 5 (14): 1569-73. PMID 16861914.
Miller JJ, Summers MK, Hansen DV, et al. (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.". Genes Dev. 20 (17): 2410-20. doi:10.1101/gad.1454006. PMID 16921029.
Marangos P, Verschuren EW, Chen R, et al. (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1).". J. Cell Biol. 176 (1): 65-75. doi:10.1083/jcb.200607070. PMID 17190794.