FBXO31

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F-box protein 31
Identifiers
Symbol(s) FBXO31; DKFZP434B027; DKFZp434J1815; FBX14; FBXO14; FLJ22477; Fbx31; MGC15419; MGC9527; pp2386
External IDs OMIM: 609102 MGI: 1354708 HomoloGene: 11684
Orthologs
Human Mouse
Entrez 79791 76454
Ensembl ENSG00000103264 ENSMUSG00000031811
Uniprot Q5XUX0 n/a
Refseq NM_024735 (mRNA)
NP_079011 (protein)		 NM_133765 (mRNA)
NP_598526 (protein)
Location Chr 16: 85.92 - 85.97 Mb Chr 8: 124.44 - 124.46 Mb
Pubmed search [1] [2]

F-box protein 31, also known as FBXO31, is a human gene.[1]

Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: FBXO31 F-box protein 31.

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Powell JA, Gardner AE, Bais AJ, et al. (2003). "Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes.". Genomics 80 (3): 303-10. PMID 12213200. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573-80. doi:10.1101/gad.1255304. PMID 15520277. 
  • Kumar R, Neilsen PM, Crawford J, et al. (2006). "FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.". Cancer Res. 65 (24): 11304-13. doi:10.1158/0008-5472.CAN-05-0936. PMID 16357137. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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