FBXO2

From Wikipedia, the free encyclopedia

F-box protein 2

PDB rendering based on 1umh.

Available structures: 1umh

Identifiers

Symbol(s)

FBXO2; FBG1; FBX2; Fbs1; NFB42

External IDs

OMIM: 607112 MGI: 2446216 HomoloGene: 8132

Gene ontology
Molecular Function:	• glycoprotein binding • ubiquitin-protein ligase activity • carbohydrate binding
Biological Process:	• proteolysis • ubiquitin cycle • glycoprotein catabolic process • protein catabolic process • ER-associated protein catabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012168 (mRNA)
NP_036300 (protein)

NM_176848 (mRNA)
NP_789818 (protein)

Location

Chr 1: 11.63 - 11.64 Mb

Chr 4: 147 - 147.01 Mb

Pubmed search

[1]

[2]

F-box protein 2, also known as FBXO2, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXO2 F-box protein 2.

[edit] Further reading

Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest.". J. Biol. Chem. 273 (52): 35222–7. PMID 9857061.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains.". Nature 418 (6896): 438–42. doi:10.1038/nature00890. PMID 12140560.
Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins.". Gene 296 (1-2): 11–20. PMID 12383498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway.". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. doi:10.1073/pnas.1733876100. PMID 12904574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.