FBXO24

From Wikipedia, the free encyclopedia

F-box protein 24

Identifiers

FBXO24; DKFZp434I1122; FBX24

External IDs

OMIM: 609097 MGI: 1918426 HomoloGene: 14131

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012172 (mRNA)
NP_036304 (protein)

XM_132440 (mRNA)
XP_132440 (protein)

Location

Chr 7: 100.02 - 100.04 Mb

Chr 5: 137.84 - 137.85 Mb

Pubmed search

[1]

[2]

F-box protein 24, also known as FBXO24, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates two transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXO24 F-box protein 24.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.