FBXO11

From Wikipedia, the free encyclopedia

F-box protein 11

Identifiers

FBXO11; FBX11; FLJ12673; MGC44383; PRMT9; UG063H01; VIT1

External IDs

OMIM: 607871 MGI: 2147134 HomoloGene: 11843

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• ubiquitin ligase complex • nucleus
Biological Process:	• ubiquitin-dependent protein catabolic process • protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012167 (mRNA)
NP_036299 (protein)

XM_001004113 (mRNA)
XP_001004113 (protein)

Location

Chr 2: 47.89 - 47.99 Mb

Chr 17: 87.9 - 87.92 Mb

Pubmed search

[1]

[2]

F-box protein 11, also known as FBXO11, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXO11 F-box protein 11.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177-9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180-2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Le Poole IC, Sarangarajan R, Zhao Y, et al. (2002). "'VIT1', a novel gene associated with vitiligo.". Pigment Cell Res. 14 (6): 475-84. PMID 11775060.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Cook JR, Lee JH, Yang ZH, et al. (2006). "FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues.". Biochem. Biophys. Res. Commun. 342 (2): 472-81. doi:10.1016/j.bbrc.2006.01.167. PMID 16487488.
Segade F, Daly KA, Allred D, et al. (2006). "Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study.". Arch. Otolaryngol. Head Neck Surg. 132 (7): 729-33. doi:10.1001/archotol.132.7.729. PMID 16847180.
Abida WM, Nikolaev A, Zhao W, et al. (2007). "FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.". J. Biol. Chem. 282 (3): 1797-804. doi:10.1074/jbc.M609001200. PMID 17098746.