FBXL3

From Wikipedia, the free encyclopedia

F-box and leucine-rich repeat protein 3

Identifiers

FBXL3; FBL3; FBL3A; FBXL3A

External IDs

OMIM: 605653 MGI: 1354702 HomoloGene: 8127

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity
Cellular Component:	• ubiquitin ligase complex • nucleus
Biological Process:	• protein ubiquitination

Orthologs

Human

Mouse

Refseq

NM_012158 (mRNA)
NP_036290 (protein)

XM_975284 (mRNA)
XP_980378 (protein)

Location

Chr 13: 76.48 - 76.5 Mb

Chr 14: 101.97 - 101.99 Mb

Pubmed search

[1]

[2]

F-box and leucine-rich repeat protein 3, also known as FBXL3, is a human gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.^[1]