FBXL2

From Wikipedia, the free encyclopedia

F-box and leucine-rich repeat protein 2

Identifiers

FBXL2; DKFZP564P0622; FBL2; FBL3

External IDs

OMIM: 605652 MGI: 1919429 HomoloGene: 32144

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• proteolysis • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012157 (mRNA)
NP_036289 (protein)

NM_178624 (mRNA)
NP_848739 (protein)

Location

Chr 3: 33.29 - 33.4 Mb

Chr 9: 113.83 - 113.87 Mb

Pubmed search

[1]

[2]

F-box and leucine-rich repeat protein 2, also known as FBXL2, is a human gene.^[1]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.^[1]

[edit] References

^ ^a ^b Entrez Gene: FBXL2 F-box and leucine-rich repeat protein 2.

[edit] Further reading

Ye J (2007). "Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.". PLoS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMID 17784784.
Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C (1999). "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats.". FEBS Lett. 459 (1): 75–9. PMID 10508920.
Cenciarelli C, Chiaur DS, Guardavaccaro D, et al. (1999). "Identification of a family of human F-box proteins.". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family.". Genomics 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wang C, Gale M, Keller BC, et al. (2005). "Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication.". Mol. Cell 18 (4): 425–34. doi:10.1016/j.molcel.2005.04.004. PMID 15893726.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.