Fatty acid-binding protein

From Wikipedia, the free encyclopedia

The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.[1] These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.[2] Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.[3]

[edit] Family members

Members of this family include:

Protein name Gene Tissue distribution Comment
FABP 1 FABP1 liver
FABP 2 FABP2 intestinal
FABP 3 FABP3 muscle and heart mammary-derived growth inhibitor
FABP 4 FABP4 adipocyte
FABP 5 FABP5 adipocyte psoriasis-associated
FABP 6 FABP6 ileal gastrotropin
FABP 7 FABP7 brain
FABP 8 PMP2 peripheral nervous system peripheral myelin protein 2
FABP 9 FABP9 testis
FABP 11 fabp11 Restricted to fishes
FABP 5-like 1 FABP5L1
FABP 5-like 2 FABP5L2
FABP 5-like 3 FABP5L3
FABP 5-like 4 FABP5L4
FABP 5-like 5 FABP5L5
FABP 5-like 6 FABP5L6
FABP 5-like 7 FABP5L7

[edit] References

  1. ^ Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. PMID 16424607. 
  2. ^ Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1-2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566. 
  3. ^ Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMID 12077340. 

[edit] External links

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