FAT (gene)

From Wikipedia, the free encyclopedia

FAT tumor suppressor homolog 1 (Drosophila)

Identifiers

FAT; CDHF7; FAT1; ME5; hFat1

External IDs

OMIM: 600976 MGI: 109168 HomoloGene: 66302

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • cell-cell signaling • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005245 (mRNA)
NP_005236 (protein)

XM_885736 (mRNA)
XP_890829 (protein)

Location

Chr 4: 187.75 - 187.88 Mb

Chr 8: 46.43 - 46.55 Mb

Pubmed search

[1]

[2]

FAT tumor suppressor homolog 1 (Drosophila), also known as FAT, is a human gene.^[1]

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila).

[edit] Further reading

Dunne J, Hanby AM, Poulsom R, et al. (1996). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.". Genomics 30 (2): 207-23. PMID 8586420.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Matsuyoshi N, Tanaka T, Toda K, Imamura S (1997). "Identification of novel cadherins expressed in human melanoma cells.". J. Invest. Dermatol. 108 (6): 908-13. PMID 9182820.
Matsuyoshi N, Imamura S (1997). "Multiple cadherins are expressed in human fibroblasts.". Biochem. Biophys. Res. Commun. 235 (2): 355-8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.". J. Cell Biol. 165 (4): 517-28. doi:10.1083/jcb.200403006. PMID 15148305.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Wu Q (2005). "Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.". Genetics 169 (4): 2179-88. doi:10.1534/genetics.104.037606. PMID 15744052.
Magg T, Schreiner D, Solis GP, et al. (2005). "Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus.". Exp. Cell Res. 307 (1): 100-8. doi:10.1016/j.yexcr.2005.03.006. PMID 15922730.
Blair IP, Chetcuti AF, Badenhop RF, et al. (2006). "Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.". Mol. Psychiatry 11 (4): 372-83. doi:10.1038/sj.mp.4001784. PMID 16402135.
Schreiner D, Müller K, Hofer HW (2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins.". FEBS Lett. 580 (22): 5295-300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Nakaya K, Yamagata HD, Arita N, et al. (2007). "Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.". Oncogene 26 (36): 5300-8. doi:10.1038/sj.onc.1210330. PMID 17325662.
Braun GS, Kretzler M, Heider T, et al. (2007). "Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells.". J. Biol. Chem. 282 (31): 22823-33. doi:10.1074/jbc.M701758200. PMID 17500054.