FARS2

From Wikipedia, the free encyclopedia

Phenylalanyl-tRNA synthetase 2, mitochondrial

Identifiers

FARS2; PheRS; FARS1; HSPC320; dJ520B18.2

External IDs

MGI: 1917205 HomoloGene: 4788

Gene ontology
Molecular Function:	• tRNA binding • nucleotide binding • phenylalanine-tRNA ligase activity • ATP binding • ligase activity
Cellular Component:	• soluble fraction • cytoplasm • mitochondrion
Biological Process:	• phenylalanyl-tRNA aminoacylation • tRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006567 (mRNA)
NP_006558 (protein)

XM_987226 (mRNA)
XP_992320 (protein)

Location

Chr 6: 5.21 - 5.72 Mb

Chr 13: 36.12 - 36.55 Mb

Pubmed search

[1]

[2]

Phenylalanyl-tRNA synthetase 2, mitochondrial, also known as FARS2, is a human gene.^[1]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.^[1]

[edit] References

^ ^a ^b Entrez Gene: FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial.

[edit] Further reading

Levin I, Kessler N, Moor N, et al. (2007). "Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetase.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 761–4. doi:10.1107/S1744309107038651. PMID 17768348.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Bullard JM, Cai YC, Demeler B, Spremulli LL (1999). "Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase.". J. Mol. Biol. 288 (4): 567–77. doi:10.1006/jmbi.1999.2708. PMID 10329163.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.