FARP2

From Wikipedia, the free encyclopedia

FERM, RhoGEF and pleckstrin domain protein 2

Identifiers

FARP2; FIR; FRG; KIAA0793; PLEKHC3

External IDs

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • binding • cytoskeletal protein binding
Cellular Component:	• intracellular • cytoplasm • cytoskeleton • membrane
Biological Process:	• neuron remodeling • Rac protein signal transduction • regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014808 (mRNA)
NP_055623 (protein)

NM_145519 (mRNA)
NP_663494 (protein)

Location

Chr 2: 241.94 - 242.08 Mb

Chr 1: 95.36 - 95.45 Mb

Pubmed search

[1]

[2]

FERM, RhoGEF and pleckstrin domain protein 2, also known as FARP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2.

[edit] Further reading

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733-45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Miyamoto Y, Yamauchi J, Itoh H (2003). "Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.". J. Biol. Chem. 278 (32): 29890-900. doi:10.1074/jbc.M301559200. PMID 12771149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kubo T, Yamashita T, Yamaguchi A, et al. (2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling.". J. Neurosci. 22 (19): 8504-13. PMID 12351724.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277-86. PMID 9872452.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.