Famciclovir

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Famciclovir
Systematic (IUPAC) name
[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate
Identifiers
CAS number	104227-87-4
ATC code	J05AB09 S01AD07
PubChem	3324
DrugBank	APRD00600
Chemical data
Formula	C14H19N5O4
Mol. mass	321.332 g/mol
Physical data
Melt. point	103 °C (217 °F)
Pharmacokinetic data
Bioavailability	75–77%
Protein binding	20-25%
Metabolism	Hepatic, circulation, intestinal wall (to penciclovir)
Half life	2–2.3 hours
Excretion	Renal, faecal
Therapeutic considerations
Pregnancy cat.	B1 (Au), B (U.S.)
Legal status	S4 (Au), POM (UK), ℞-only (U.S.)
Routes	Oral

Famciclovir (INN) (pronounced /pɛnˈsaɪkloʊvɪr/) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).

On August 24, 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic Famciclovir Tablets (125 mg, 250 mg, 500 mg) are manufactured by Kfar-Sava, Israel-based TEVA Pharmaceuticals. ^[1]

Contents 1 Clinical use 1.1 Indications and dosage forms 2 Adverse effects 3 Footnotes 4 External links 5 See also

[edit] Clinical use

[edit] Indications and dosage forms

Famciclovir comes as a tablet to take by mouth. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days.^[2] It is also sometimes given in one single large dose as opposed to several days of scheduled small doses. Among other side effects, Famciclovir may cause an upset stomach. Take famciclovir with food or milk.^[2]

[edit] Adverse effects

Side effects: mild to extreme stomach upset, headaches, mild fever.

[edit] Footnotes

[edit] External links

• Famvir product website

[edit] See also

• Penciclovir

v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) Anti-herpesvirus (DNA, I) guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine HPV/MC (DNA, I) Imiquimod • Podophyllotoxin Hepatitis B (DNA, VII) Adefovir • Clevudine • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir† Hepatitis C (RNA, IV) Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir† Picornavirus (RNA, IV) Pleconaril† Anti-influenza agents (RNA, V) Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†) HIV (Reverse, VI) See HIV pharm Other antiviral agents general (Inosine, Interferon) †Undergoing clinical trials, not FDA approved.