FAM19A1

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Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
Identifiers
Symbol(s) FAM19A1; TAFA-1; TAFA1
External IDs MGI: 2443695 HomoloGene: 45655
Orthologs
Human Mouse
Entrez 407738 320265
Ensembl ENSG00000183662 ENSMUSG00000059187
Uniprot Q7Z5A9 Q7TPG8
Refseq NM_213609 (mRNA)
NP_998774 (protein)		 NM_182808 (mRNA)
NP_877960 (protein)
Location Chr 3: 68.14 - 68.69 Mb Chr 6: 96.08 - 96.61 Mb
Pubmed search [1] [2]

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1, also known as FAM19A1, is a human gene.[1]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.[1]

[edit] References

  1. ^ a b Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1.

[edit] Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Tom Tang Y, Emtage P, Funk WD, et al. (2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain.". Genomics 83 (4): 727-34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
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