FADS1

From Wikipedia, the free encyclopedia

Fatty acid desaturase 1

Identifiers

FADS1; D5D; FADS6; FADSD5; FLJ38956; FLJ90273; LLCDL1; TU12

External IDs

OMIM: 606148 MGI: 1923517 HomoloGene: 22753

Gene ontology
Molecular Function:	• iron ion binding • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water • heme binding
Cellular Component:	• membrane fraction • microsome • membrane • integral to membrane
Biological Process:	• lipid metabolic process • fatty acid desaturation • cell-cell signaling • phospholipid biosynthetic process • cellular response to starvation • regulation of transcription • regulation of cell differentiation • icosanoid biosynthetic process

Orthologs

Human

Mouse

n/a

Refseq

NM_013402 (mRNA)
NP_037534 (protein)

NM_146094 (mRNA)
NP_666206 (protein)

Location

n/a

Chr 19: 10.25 - 10.26 Mb

Pubmed search

[1]

[2]

Fatty acid desaturase 1, also known as FADS1, is a human gene.^[1]

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.^[1]

[edit] References

^ ^a ^b Entrez Gene: FADS1 fatty acid desaturase 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Stöhr H, Marquardt A, Rivera A, et al. (1998). "A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1.". Genome Res. 8 (1): 48-56. PMID 9445487.
Cho HP, Nakamura M, Clarke SD (2000). "Cloning, expression, and fatty acid regulation of the human delta-5 desaturase.". J. Biol. Chem. 274 (52): 37335-9. PMID 10601301.
Leonard AE, Kelder B, Bobik EG, et al. (2000). "cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.". Biochem. J. 347 Pt 3: 719-24. PMID 10769175.
Marquardt A, Stöhr H, White K, Weber BH (2000). "cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.". Genomics 66 (2): 175-83. doi:10.1006/geno.2000.6196. PMID 10860662.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Brizio C, Galluccio M, Wait R, et al. (2006). "Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase.". Biochem. Biophys. Res. Commun. 344 (3): 1008-16. doi:10.1016/j.bbrc.2006.04.003. PMID 16643857.
Schaeffer L, Gohlke H, Müller M, et al. (2006). "Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids.". Hum. Mol. Genet. 15 (11): 1745-56. doi:10.1093/hmg/ddl117. PMID 16670158.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63-72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Dreesen TD, Adamson AW, Tekle M, et al. (2006). "A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase.". Prostaglandins Leukot. Essent. Fatty Acids 75 (2): 97-106. doi:10.1016/j.plefa.2006.05.001. PMID 16846730.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Risé P, Ghezzi S, Carissimi R, et al. (2007). "Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.". Eur. J. Pharmacol. 571 (2-3): 97-105. doi:10.1016/j.ejphar.2007.06.021. PMID 17655842.