Talk:Factor V Leiden
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[edit] I
I suffer with this condition and was wondering what medication people are given?
- It is not really a condition but a risk factor. It requires no specific treatment unless there are complications, in which case these are treated normally. JFW | T@lk 09:14, 30 December 2005 (UTC)
[edit] Role in sex of child
My mother suffers this disorder. The doctors told her that it is very unlike to have a female child, and in case of having female child, it would be very probable that it would not be "normal" healthy child. How much of it is true? True is, that she has two children, two boys. They found that my brother is carrier as well. Is it possible that the mutation is sex chromosom linked? Because the doctors say that it won't have any effect on my brother or his children anymore. I would love to know ANY more information about this mutation. Thanks Alllfff
- I have never heard of this before. Factor V homozygosity is associated with a higher rate of miscarriage, but the genotype of the child or the sex is completely independent of this phenomenon (unless I have missed a paper on this). The mutation is not sex chromosome linked; the first chromosome is autosomal. Are you sure it is factor V your family has been diagnosed with? JFW | T@lk 15:04, 12 February 2006 (UTC)
- A study in Denmark measuring the prevalence of factor V Leiden among newborns found that the gene was equally distributed between male and female children. --Ipeltan 01:21, 27 March 2006 (UTC)
I'm not sure what is the different between Factor V and Leiden Mutation, but the doctors said Leiden Mutation. Btw, thank you so much for the information writen here so far!--Alllfff 11:45, 1 April 2006 (UTC)
- The Leiden mutation is a specific mutation within the gene that encodes a coagulation protein called "factor V." Both the mutation and the hypercoagulable condition it causes may be referred to as "factor V Leiden." The mutation, which changes a single DNA base pair, is called "Leiden" because the scientists who identified it worked at the University of Leiden in Sweden. Other mutations in this protein that may or may not cause problems have been given the names "factor V Cambridge" and "factor V Hong Kong" for the same reason. --Ipeltan 19:05, 2 April 2006 (UTC)
Hey, Leiden is not in Sweden, thank you very much! :-) JFW | T@lk 22:48, 2 April 2006 (UTC)
- My apologies! Silly mistake, I was just thinking of the folks in Sweden who first identified the phenotype of activated protein C resistance. --Ipeltan 17:19, 3 April 2006 (UTC)
[edit] Capitalization of factor V Leiden
A casual search of PubMed shows that the overwhelming majority of references to "factor V Ledien" have "factor V" in lower case. This should be reflected in the article. Andrew73 02:48, 15 May 2006 (UTC)
- Second apology on this page! I read the history comparison backward before I made that revert. My mistake. --Ipeltan 04:06, 15 May 2006 (UTC)
I have Factor V Leiden - 37 yr old female. My first pregnancy at age 30 was riddled with problems including preeclampsia w/bedrest. Our baby boy was stillborn at 38 wks. Genetic testing showed the Factor V Leiden mutation. Since, on the recommendation of my doctor, I have taken Folbee Plus (high dose folic acid w/B Vitamins) and had a successful pregnancy - also a boy. I would be interested to hear more about the mutation causing women to bear mostly boys or a possibility of having an "abnormal" girl.
- This is not standard treatment. Folic acid and B vitamins would be useful in homocysteinaemia (which is also linked to pregnancy complications of the type you describe). But in FVL I suspect the better treatment would be enoxaparin sodium - that is the one that has been actually proven to be working in clinical trials anyway. JFW | T@lk 19:54, 3 July 2007 (UTC)
[edit] V
Is the V in Factor V Leiden a V or a roman 5 (therefore would be pronounced Factor Five Leiden)? 90.129.0.158 20:34, 9 May 2007 (UTC)
- It is a "five". See coagulation for an explanation of the nomenclature. JFW | T@lk 19:54, 3 July 2007 (UTC)
[edit] Impact
PMID 14996674 shows the 3x increased thrombosis risk and 18x in homozygotes. JFW | T@lk 19:54, 3 July 2007 (UTC)
[edit] Should I be tested for FVL
My half sister recently found out she has factor 5 Leiden. She has had difficulty with blood clots for most of her adult life. We had the same father, but not the same mother. My brother,(full brother, we share the same mother and father) recently had himself tested before surgery and his test came back negative. Does this mean I would be negative also? Or is there a chance that I would have the abnormality? We do not know which parent my half sister received this from, or if she received it from both for that matter. My father has passed and therefore cannot be tested. Any info in laymans terms would be very helpful. Thank you. [REMOVED E-MAIL ADDRESS]
[edit] Rate of Recurrent Clotting in FVL+ Patients
What is the rate of recurring clotting episodes for FVL+ patients? Are there any other ways to reduce the risk other than taking warfarin or heperin? Thank you.
- The risk depends on whether the FVL is homo- or heterozygous, and whether there are other risk factors for recurrence (such as antiphospholipid antibodies, prothrombin mutation, etc). FVL is not a modifiable risk factor, but addressing all other risk factors is a way to reduce risk. Aspirin is not generally recommended; most studies show limited benefit in venous thrombosis. JFW | T@lk 14:44, 24 February 2008 (UTC)
[edit] chances of having a child period?
my doctor told me iam unable to have children ever again! can anyone tell me different? have factor V leiden and lupus anticoagulant? because i would really like to have another child my son is 5 and i did have problems during my pregancy{i.e hemorage,low birth wieght and 18 days early Please i relly need some answers? CDW 11-01-07 —Preceding unsigned comment added by 68.189.202.57 (talk) 01:47, 2 November 2007 (UTC)
- Please, you really need to talk to your doctor! Don't take the word of random strangers. WhatamIdoing (talk) 05:42, 23 February 2008 (UTC)
- Agree - Wikipedia is not a place to get medical advice. Much work is being done in this area. Discuss with your doctor; there are specialists with an interest in this kind of problem. JFW | T@lk 14:44, 24 February 2008 (UTC)
[edit] Distal DVT
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2007.02883.x - I can't get the fulltext but it seems FVL is more likely to cause distal as opposed to proximal DVTs. JFW | T@lk 14:44, 24 February 2008 (UTC)
[edit] Factor V in children
My husband recently found out that he has Factor V Leiden after being diagnosed with a DVT. I read above, if I'm interpreting what was said correctly, that aspirin therapy has not been succuessful in preventing more clots? What is the usual treatment for this disease? He is on coumadin now for the DVT, but told he'd take that for about 6 months and then probably be on aspirin therapy the rest of his life. He is heterozygous for this condition. We have since tested both of our daughters for this condition (they are ages 3 1/2 and 6) and found that they are both also heterozygous for Factor V. What is the treatment if any for children? Are there precautions I should take for them? I found out after a couple miscarriages trying to have our second daughter that I have antiphospholipid anticardiolipin clotting disorder. I've been told this is not hereditary. Do you know if that is true? I'd hate for my daughters to have an even greater risk. Thanks in advance for any help. 72.75.220.87 (talk) 19:55, 11 March 2008 (UTC)momfits
[edit] References
This article definitely needs more references. "Studies show..." Great, which studies? Neoprote (talk) 11:34, 20 May 2008 (UTC)
