FABP7

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Fatty acid binding protein 7, brain
PDB rendering based on 1fdq.
Available structures: 1fdq, 1fe3, 1jjx
Identifiers
Symbol(s) FABP7; B-FABP; BLBP; DKFZp547J2313; FABPB; MRG
External IDs OMIM: 602965 MGI: 101916 HomoloGene: 37880
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2173 12140
Ensembl ENSG00000164434 ENSMUSG00000019874
Uniprot O15540 Q4FJK4
Refseq NM_001446 (mRNA)
NP_001437 (protein)		 XM_975801 (mRNA)
XP_980895 (protein)
Location Chr 6: 123.14 - 123.15 Mb Chr 10: 57.47 - 57.48 Mb
Pubmed search [1] [2]

Fatty acid binding protein 7, brain, also known as FABP7, is a human gene.[1] The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[1]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.
Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.


[edit] References

  1. ^ a b Entrez Gene: FABP7 fatty acid binding protein 7, brain.

[edit] Further reading

  • Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation.". Prostaglandins Leukot. Essent. Fatty Acids 57 (1): 77–84. PMID 9250612. 
  • Xu LZ, Sánchez R, Sali A, Heintz N (1996). "Ligand specificity of brain lipid-binding protein.". J. Biol. Chem. 271 (40): 24711–9. PMID 8798739. 
  • Young JK, Baker JH, Muller T (1997). "Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes.". Glia 16 (3): 218–26. doi:10.1002/(SICI)1098-1136(199603)16:3<218::AID-GLIA4>3.0.CO;2-Y. PMID 8833192. 
  • Shi YE, Ni J, Xiao G, et al. (1997). "Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG.". Cancer Res. 57 (15): 3084–91. PMID 9242429. 
  • Shimizu F, Watanabe TK, Shinomiya H, et al. (1997). "Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP).". Biochim. Biophys. Acta 1354 (1): 24–8. PMID 9375786. 
  • Godbout R, Bisgrove DA, Shkolny D, Day RS (1998). "Correlation of B-FABP and GFAP expression in malignant glioma.". Oncogene 16 (15): 1955–62. doi:10.1038/sj.onc.1201740. PMID 9591779. 
  • Pu L, Igbavboa U, Wood WG, et al. (1999). "Expression of fatty acid binding proteins is altered in aged mouse brain.". Mol. Cell. Biochem. 198 (1-2): 69–78. PMID 10497880. 
  • Balendiran GK, Schnutgen F, Scapin G, et al. (2000). "Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.". J. Biol. Chem. 275 (35): 27045–54. doi:10.1074/jbc.M003001200. PMID 10854433. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rademacher M, Zimmerman AW, Rüterjans H, et al. (2003). "Solution structure of fatty acid-binding protein from human brain.". Mol. Cell. Biochem. 239 (1-2): 61–8. PMID 12479569. 
  • Miller SJ, Li H, Rizvi TA, et al. (2003). "Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis.". Mol. Cell. Biol. 23 (6): 2213–24. PMID 12612091. 
  • Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (2003). "Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance.". Nucleic Acids Res. 31 (11): 2769–77. PMID 12771203. 
  • Wang M, Liu YE, Goldberg ID, Shi YE (2004). "Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG.". J. Biol. Chem. 278 (47): 47319–25. doi:10.1074/jbc.M308131200. PMID 12975368. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Liang Y, Diehn M, Watson N, et al. (2005). "Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.". Proc. Natl. Acad. Sci. U.S.A. 102 (16): 5814–9. doi:10.1073/pnas.0402870102. PMID 15827123. 
  • Liang Y, Bollen AW, Aldape KD, Gupta N (2006). "Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma.". BMC Cancer 6: 97. doi:10.1186/1471-2407-6-97. PMID 16623952. 
  • Kaloshi G, Mokhtari K, Carpentier C, et al. (2007). "FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status.". J. Neurooncol. 84 (3): 245–8. doi:10.1007/s11060-007-9377-4. PMID 17415524. 
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