FABP6

From Wikipedia, the free encyclopedia

Fatty acid binding protein 6, ileal (gastrotropin)

PDB rendering based on 1o1u.

Available structures: 1o1u, 1o1v

Identifiers

Symbol(s)

FABP6; I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP

External IDs

OMIM: 600422 MGI: 96565 HomoloGene: 1108

Gene ontology
Molecular Function:	• fatty acid binding • lipid binding
Cellular Component:	• cytoplasm
Biological Process:	• lipid metabolic process • transport • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040442 (mRNA)
NP_001035532 (protein)

NM_008375 (mRNA)
NP_032401 (protein)

Location

Chr 5: 159.57 - 159.6 Mb

Chr 11: 43.44 - 43.44 Mb

Pubmed search

[1]

[2]

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a human gene.^[1]

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin).

[edit] Further reading

Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation.". Prostaglandins Leukot. Essent. Fatty Acids 57 (1): 77–84. PMID 9250612.
Fujita M, Fujii H, Kanda T, et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein.". Eur. J. Biochem. 233 (2): 406–13. PMID 7588781.
Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein.". Biochim. Biophys. Acta 1257 (2): 199–202. PMID 7619861.
Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11.". Mamm. Genome 5 (12): 805–6. PMID 7894165.
Watanabe K, Hoshi N, Tsuura Y, et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues.". Arch. Histol. Cytol. 58 (3): 303–6. PMID 8527237.
Lücke C, Zhang F, Rüterjans H, et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.". Structure 4 (7): 785–800. PMID 8805562.
Grober J, Zaghini I, Fujii H, et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer.". J. Biol. Chem. 274 (42): 29749–54. PMID 10514450.
Seibert C, Harteneck C, Ernst OP, et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells.". Eur. J. Biochem. 266 (3): 911–6. PMID 10583385.
Lücke C, Zhang F, Hamilton JA, et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate.". Eur. J. Biochem. 267 (10): 2929–38. PMID 10806391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kurz M, Brachvogel V, Matter H, et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures.". Proteins 50 (2): 312–28. doi:10.1002/prot.10289. PMID 12486725.
Barley NF, Taylor V, Shaw-Smith CJ, et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2.". Biochim. Biophys. Acta 1630 (2-3): 138–43. PMID 14654244.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Landrier JF, Thomas C, Grober J, et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors.". Biochim. Biophys. Acta 1735 (1): 41–9. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
Ohmachi T, Inoue H, Mimori K, et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer.". Clin. Cancer Res. 12 (17): 5090–5. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.
Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma.". Cancer Res. 67 (19): 9039–46. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.