FABP5

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Fatty acid binding protein 5 (psoriasis-associated)
PDB rendering based on 1b56.
Available structures: 1b56, 1jjj
Identifiers
Symbol(s) FABP5; E-FABP; EFABP; PA-FABP; PAFABP
External IDs OMIM: 605168 HomoloGene: 88646
Orthologs
Human Mouse
Entrez 2171 628298


Refseq NM_001444 (mRNA)
NP_001435 (protein)		 NM_001081334 (mRNA)
NP_001074803 (protein)
Pubmed search [1] [2]

Fatty acid binding protein 5 (psoriasis-associated), also known as FABP5, is a human gene.[1]

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[1]

[edit] References

  1. ^ a b Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated).

[edit] Further reading

  • Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. PMID 1286667. 
  • Madsen P, Rasmussen HH, Leffers H, et al. (1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.". J. Invest. Dermatol. 99 (3): 299–305. PMID 1512466. 
  • Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1994). "Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro.". Biochem. J. 302 ( Pt 2): 363–71. PMID 8092987. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP).". Biochem. Biophys. Res. Commun. 190 (2): 482–7. PMID 8427590. 
  • Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study.". Dermatology (Basel) 192 (3): 208–13. PMID 8726632. 
  • Jaworski C, Wistow G (1997). "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens.". Biochem. J. 320 ( Pt 1): 49–54. PMID 8947466. 
  • Masouyé I, Hagens G, Van Kuppevelt TH, et al. (1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein.". Circ. Res. 81 (3): 297–303. PMID 9285630. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Watanabe R, Fujii H, Yamamoto A, et al. (1998). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin.". J. Dermatol. Sci. 16 (1): 17–22. PMID 9438903. 
  • Hagens G, Masouyé I, Augsburger E, et al. (1999). "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes.". Biochem. J. 339 ( Pt 2): 419–27. PMID 10191275. 
  • Hagens G, Roulin K, Hotz R, et al. (1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales.". Mol. Cell. Biochem. 192 (1-2): 123–8. PMID 10331666. 
  • Hohoff C, Börchers T, Rüstow B, et al. (1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein.". Biochemistry 38 (38): 12229–39. PMID 10493790. 
  • O'Shaughnessy RF, Seery JP, Celis JE, et al. (2001). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation.". FEBS Lett. 486 (2): 149–54. PMID 11113456. 
  • Gutiérrez-González LH, Ludwig C, Hohoff C, et al. (2002). "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).". Biochem. J. 364 (Pt 3): 725–37. doi:10.1042/BJ20020039. PMID 12049637. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Ruse M, Broome AM, Eckert RL (2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes.". J. Invest. Dermatol. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573. 
  • Ha MK, Chung KY, Lee JH, et al. (2005). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells.". Exp. Dermatol. 13 (9): 543–50. doi:10.1111/j.0906-6705.2004.00196.x. PMID 15335354. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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