EXTL3

From Wikipedia, the free encyclopedia

Exostoses (multiple)-like 3

Identifiers

EXTL3; DKFZp686C2342; EXTR1; KIAA0519; REG; REGR; RPR; botv

External IDs

OMIM: 605744 MGI: 1860765 HomoloGene: 1103

Gene ontology
Molecular Function:	• glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity • transferase activity, transferring glycosyl groups • manganese ion binding • metal ion binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001440 (mRNA)
NP_001431 (protein)

NM_018788 (mRNA)
NP_061258 (protein)

Location

Chr 8: 28.62 - 28.67 Mb

Chr 14: 64.01 - 64.03 Mb

Pubmed search

[1]

[2]

Exostoses (multiple)-like 3, also known as EXTL3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EXTL3 exostoses (multiple)-like 3.

[edit] Further reading

Wuyts W, Van Hul W, Hendrickx J, et al. (1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2.". Eur. J. Hum. Genet. 5 (6): 382–9. PMID 9450183.
Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.". Biochem. Biophys. Res. Commun. 243 (1): 61–6. PMID 9473480.
Van Hul W, Wuyts W, Hendrickx J, et al. (1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family.". Genomics 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. PMID 10639137.
Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor.". J. Biol. Chem. 275 (15): 10723–6. PMID 10753861.
Mizuno K, Irie S, Sato TA (2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha.". Cell. Signal. 13 (2): 125–30. PMID 11257457.
Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes.". Cancer Biol. Ther. 5 (12): 1714–20. PMID 17106246.