Exosome component 8

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Exosome component 8

PDB rendering based on 2nn6.

Available structures: 2nn6

Identifiers

Symbol(s)

EXOSC8; CIP3; EAP2; OIP2; RP11-421P11.3; RRP43; Rrp43p; bA421P11.3; p9

External IDs

OMIM: 606019 MGI: 1916889 HomoloGene: 12323

Gene ontology
Molecular Function:	• 3'-5'-exoribonuclease activity • molecular_function • RNA binding • exonuclease activity • hydrolase activity • identical protein binding
Cellular Component:	• exosome (RNase complex) • cellular_component • nucleus
Biological Process:	• rRNA processing • RNA processing • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_181503 (mRNA)
NP_852480 (protein)

NM_027148 (mRNA)
NP_081424 (protein)

Location

Chr 13: 36.47 - 36.48 Mb

Chr 3: 54.82 - 54.82 Mb

Pubmed search

[1]

[2]

Exosome component 8, also known as EXOSC8, is a human gene.^[1]

[edit] References

^ Entrez Gene: EXOSC8 exosome component 8.

[edit] Further reading

Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. PMID 12419256.
Jiang T, Altman S (2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5295–300. doi:10.1073/pnas.072083699. PMID 11929972.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. PMID 11719186.
Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P.". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMID 11158571.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
Williams JM, Chen GC, Zhu L, Rest RF (1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.". Mol. Microbiol. 27 (1): 171–86. PMID 9466265.